Modular reconstruction and optimization of the trans-4-hydroxy-L-proline synthesis pathway in Escherichia coli

Modular reconstruction and optimization of the trans-4-hydroxy-L-proline synthesis pathway in Escherichia coli

Abstract Background In recent years, there has been a growing demand for microbial production of trans-4-hydroxy-L-proline (t4Hyp), which is a value-added amino acid and has been widely used in the fields of medicine, food, and cosmetics. In this study, a multivariate modular metabolic engineering a...

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Bibliographic Details
Main Authors: Zhenyu Zhang, Weike Su, Yunyun Bao, Qianqian Huang, Kai Ye, Pengfu Liu, Xiaohe Chu
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Microbial Cell Factories
Subjects:
Trans-4-hydroxy-L-proline
Escherichia coli
Modular metabolic engineering
Metabolic balance
Online Access:https://doi.org/10.1186/s12934-022-01884-4

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