Recent Advances in the Control of Clinically Important Biofilms
Biofilms are complex structures formed by bacteria, fungi, or even viruses on biotic and abiotic surfaces, and they can be found in almost any part of the human body. The prevalence of biofilm-associated diseases has increased in recent years, mainly because of the frequent use of indwelling medical...
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/17/9526 |
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| author | Katarzyna Krukiewicz Alicja Kazek-Kęsik Monika Brzychczy-Włoch Marek J. Łos Collins Njie Ateba Parvaneh Mehrbod Saeid Ghavami Divine Yufetar Shyntum |
| author_facet | Katarzyna Krukiewicz Alicja Kazek-Kęsik Monika Brzychczy-Włoch Marek J. Łos Collins Njie Ateba Parvaneh Mehrbod Saeid Ghavami Divine Yufetar Shyntum |
| author_sort | Katarzyna Krukiewicz |
| collection | DOAJ |
| description | Biofilms are complex structures formed by bacteria, fungi, or even viruses on biotic and abiotic surfaces, and they can be found in almost any part of the human body. The prevalence of biofilm-associated diseases has increased in recent years, mainly because of the frequent use of indwelling medical devices that create opportunities for clinically important bacteria and fungi to form biofilms either on the device or on the neighboring tissues. As a result of their resistance to antibiotics and host immunity factors, biofilms have been associated with the development or persistence of several clinically important diseases. The inability to completely eradicate biofilms drastically increases the burden of disease on both the patient and the healthcare system. Therefore, it is crucial to develop innovative ways to tackle the growth and development of biofilms. This review focuses on dental- and implant-associated biofilm infections, their prevalence in humans, and potential therapeutic intervention strategies, including the recent advances in pharmacology and biomedical engineering. It lists current strategies used to control the formation of clinically important biofilms, including novel antibiotics and their carriers, antiseptics and disinfectants, small molecule anti-biofilm agents, surface treatment strategies, and nanostructure functionalization, as well as multifunctional coatings particularly suitable for providing antibacterial effects to the surface of implants, to treat either dental- or implant-related bacterial infections. |
| first_indexed | 2024-03-10T01:47:42Z |
| format | Article |
| id | doaj.art-fe298a3c427348daa76806729dbc2e03 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:47:42Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fe298a3c427348daa76806729dbc2e032023-11-23T13:12:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012317952610.3390/ijms23179526Recent Advances in the Control of Clinically Important BiofilmsKatarzyna Krukiewicz0Alicja Kazek-Kęsik1Monika Brzychczy-Włoch2Marek J. Łos3Collins Njie Ateba4Parvaneh Mehrbod5Saeid Ghavami6Divine Yufetar Shyntum7Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M. Strzody 9, 44-100 Gliwice, PolandDepartment of Inorganic Chemistry, Analytical Chemistry and Electrochemistry, Silesian University of Technology, 44-100 Gliwice, PolandDepartment of Molecular Medical Microbiology, Chair of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, Czysta 18 Street, 31-121 Krakow, PolandDepartment of Pathology, Pomeranian Medical University, 71-344 Szczecin, PolandFood Security and Safety Niche Area, North West University, Private Bag X2046, Mahikeng 2735, South AfricaInfluenza and Respiratory Viruses Department, Pasteur Institute of Iran, Tehran 1316943551, IranFaculty of Medicine in Zabrze, University of Technology in Katowice, Academia of Silesia, 41-800 Zabrze, PolandBiotechnology Centre, Silesian University of Technology, Krzywoustego 8 Street, 44-100 Gliwice, PolandBiofilms are complex structures formed by bacteria, fungi, or even viruses on biotic and abiotic surfaces, and they can be found in almost any part of the human body. The prevalence of biofilm-associated diseases has increased in recent years, mainly because of the frequent use of indwelling medical devices that create opportunities for clinically important bacteria and fungi to form biofilms either on the device or on the neighboring tissues. As a result of their resistance to antibiotics and host immunity factors, biofilms have been associated with the development or persistence of several clinically important diseases. The inability to completely eradicate biofilms drastically increases the burden of disease on both the patient and the healthcare system. Therefore, it is crucial to develop innovative ways to tackle the growth and development of biofilms. This review focuses on dental- and implant-associated biofilm infections, their prevalence in humans, and potential therapeutic intervention strategies, including the recent advances in pharmacology and biomedical engineering. It lists current strategies used to control the formation of clinically important biofilms, including novel antibiotics and their carriers, antiseptics and disinfectants, small molecule anti-biofilm agents, surface treatment strategies, and nanostructure functionalization, as well as multifunctional coatings particularly suitable for providing antibacterial effects to the surface of implants, to treat either dental- or implant-related bacterial infections.https://www.mdpi.com/1422-0067/23/17/9526anti-biofilm agentbacterial biofilmbacterial infectionmedical deviceantimicrobial resistanceantibacterial therapy |
| spellingShingle | Katarzyna Krukiewicz Alicja Kazek-Kęsik Monika Brzychczy-Włoch Marek J. Łos Collins Njie Ateba Parvaneh Mehrbod Saeid Ghavami Divine Yufetar Shyntum Recent Advances in the Control of Clinically Important Biofilms International Journal of Molecular Sciences anti-biofilm agent bacterial biofilm bacterial infection medical device antimicrobial resistance antibacterial therapy |
| title | Recent Advances in the Control of Clinically Important Biofilms |
| title_full | Recent Advances in the Control of Clinically Important Biofilms |
| title_fullStr | Recent Advances in the Control of Clinically Important Biofilms |
| title_full_unstemmed | Recent Advances in the Control of Clinically Important Biofilms |
| title_short | Recent Advances in the Control of Clinically Important Biofilms |
| title_sort | recent advances in the control of clinically important biofilms |
| topic | anti-biofilm agent bacterial biofilm bacterial infection medical device antimicrobial resistance antibacterial therapy |
| url | https://www.mdpi.com/1422-0067/23/17/9526 |
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