Serum folate levels and cognitive performance in the ELSA-Brasil baseline assessment
ABSTRACT Background: Most studies that analyze the association between serum folate levels and cognitive function either restrict their assessments to specific clinical scenarios or do not include middle-aged individuals, to whom strategies for preventing cognitive impairment may be more feasible....
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2020-11-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020001100672&tlng=en |
| _version_ | 1798020352704512000 |
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| author | Itamar de Souza SANTOS Claudia Kimie SUEMOTO José Benedito Ramos VALLADÃO-JUNIOR Simin LIU Sandhi Maria BARRETO Ligia Maria Giongo FEDELI Paulo Andrade LOTUFO Isabela Martins BENSENOR |
| author_facet | Itamar de Souza SANTOS Claudia Kimie SUEMOTO José Benedito Ramos VALLADÃO-JUNIOR Simin LIU Sandhi Maria BARRETO Ligia Maria Giongo FEDELI Paulo Andrade LOTUFO Isabela Martins BENSENOR |
| author_sort | Itamar de Souza SANTOS |
| collection | DOAJ |
| description | ABSTRACT Background: Most studies that analyze the association between serum folate levels and cognitive function either restrict their assessments to specific clinical scenarios or do not include middle-aged individuals, to whom strategies for preventing cognitive impairment may be more feasible. Objective: To examine the association between serum folate levels and cognitive function in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline assessment. Methods: Data from 4,571 ELSA-Brasil participants who live in the state of São Paulo, aged 35-74 years, were analyzed. The word list learning, delayed recall, word recognition, verbal fluency, and Trail Making Test Part B consisted in the cognitive tests. For each test, age, sex, and education-specific standardized scores and a global cognitive score were calculated. Crude and adjusted linear regression models were used to examine the associations of serum folate levels with cognitive test scores. Results: In multivariable-adjusted models, serum folate was not associated with global cognitive score (β=-0.043; 95% confidence interval [95%CI] -0.135 to 0.050 for lowest vs. highest quintile group), nor with any cognitive test performance. We did not find associations between serum folate and global cognitive scores in subgroups stratified by age, sex, or use of vitamin supplements either. Conclusions: We did not find significant associations between serum folate and cognitive performance in this large sample, which is characterized by a context of food fortification policies and a consequent low frequency of folate deficiency. Positive results from previous studies may not apply to the increasingly common contexts in which food fortification is implemented, or to younger individuals. |
| first_indexed | 2024-04-11T16:55:04Z |
| format | Article |
| id | doaj.art-fe2d85d0ed1a482aa095578dd66151d7 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-04-11T16:55:04Z |
| publishDate | 2020-11-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-fe2d85d0ed1a482aa095578dd66151d72022-12-22T04:13:17ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272020-11-01781167268010.1590/0004-282x20200074Serum folate levels and cognitive performance in the ELSA-Brasil baseline assessmentItamar de Souza SANTOShttps://orcid.org/0000-0003-3212-8466Claudia Kimie SUEMOTOhttps://orcid.org/0000-0002-5942-4778José Benedito Ramos VALLADÃO-JUNIORhttps://orcid.org/0000-0002-0136-4872Simin LIUhttps://orcid.org/0000-0003-2098-3844Sandhi Maria BARRETOhttps://orcid.org/0000-0001-7383-7811Ligia Maria Giongo FEDELIhttps://orcid.org/0000-0002-5540-5668Paulo Andrade LOTUFOhttps://orcid.org/0000-0002-4856-8450Isabela Martins BENSENORhttps://orcid.org/0000-0002-6723-5678ABSTRACT Background: Most studies that analyze the association between serum folate levels and cognitive function either restrict their assessments to specific clinical scenarios or do not include middle-aged individuals, to whom strategies for preventing cognitive impairment may be more feasible. Objective: To examine the association between serum folate levels and cognitive function in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline assessment. Methods: Data from 4,571 ELSA-Brasil participants who live in the state of São Paulo, aged 35-74 years, were analyzed. The word list learning, delayed recall, word recognition, verbal fluency, and Trail Making Test Part B consisted in the cognitive tests. For each test, age, sex, and education-specific standardized scores and a global cognitive score were calculated. Crude and adjusted linear regression models were used to examine the associations of serum folate levels with cognitive test scores. Results: In multivariable-adjusted models, serum folate was not associated with global cognitive score (β=-0.043; 95% confidence interval [95%CI] -0.135 to 0.050 for lowest vs. highest quintile group), nor with any cognitive test performance. We did not find associations between serum folate and global cognitive scores in subgroups stratified by age, sex, or use of vitamin supplements either. Conclusions: We did not find significant associations between serum folate and cognitive performance in this large sample, which is characterized by a context of food fortification policies and a consequent low frequency of folate deficiency. Positive results from previous studies may not apply to the increasingly common contexts in which food fortification is implemented, or to younger individuals.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020001100672&tlng=enCognitionDietary SupplementsEpidemiologyFolic AcidMemory |
| spellingShingle | Itamar de Souza SANTOS Claudia Kimie SUEMOTO José Benedito Ramos VALLADÃO-JUNIOR Simin LIU Sandhi Maria BARRETO Ligia Maria Giongo FEDELI Paulo Andrade LOTUFO Isabela Martins BENSENOR Serum folate levels and cognitive performance in the ELSA-Brasil baseline assessment Arquivos de Neuro-Psiquiatria Cognition Dietary Supplements Epidemiology Folic Acid Memory |
| title | Serum folate levels and cognitive performance in the ELSA-Brasil baseline assessment |
| title_full | Serum folate levels and cognitive performance in the ELSA-Brasil baseline assessment |
| title_fullStr | Serum folate levels and cognitive performance in the ELSA-Brasil baseline assessment |
| title_full_unstemmed | Serum folate levels and cognitive performance in the ELSA-Brasil baseline assessment |
| title_short | Serum folate levels and cognitive performance in the ELSA-Brasil baseline assessment |
| title_sort | serum folate levels and cognitive performance in the elsa brasil baseline assessment |
| topic | Cognition Dietary Supplements Epidemiology Folic Acid Memory |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020001100672&tlng=en |
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