Mutation or loss of Wilms' tumor gene 1 (WT1) are not major reasons for immune escape in patients with AML receiving WT1 peptide vaccination

Mutation or loss of Wilms' tumor gene 1 (WT1) are not major reasons for immune escape in patients with AML receiving WT1 peptide vaccination

<p>Abstract</p> <p>Background</p> <p>Efficacy of cancer vaccines may be limited due to immune escape mechanisms like loss or mutation of target antigens. Here, we analyzed 10 HLA-A2 positive patients with acute myeloid leukemia (AML) for loss or mutations of the WT1 epi...

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Bibliographic Details
Main Authors: Ochsenreither Sebastian, Nonnenmacher Anika, Scheibenbogen Carmen, Letsch Anne, Busse Antonia, Thiel Eckhard, Keilholz Ulrich
Format: Article
Language:English
Published: BMC 2010-01-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/8/1/5

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