In vivo retention and bioactivity of IL‐1ra microspheres in the rat intervertebral disc: a preliminary investigation

In vivo retention and bioactivity of IL‐1ra microspheres in the rat intervertebral disc: a preliminary investigation

Abstract Background Inflammatory cytokines such as interleukin‐1 beta (IL‐1β) contribute to the progression of intervertebral disc degeneration. Previously we demonstrated, in vitro, that by delivering interleukin‐1 receptor antagonist (IL‐1ra) from poly(lactic co‐glycolic acid) (PLGA) microspheres,...

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Bibliographic Details
Main Authors: Deborah J Gorth, John T Martin, George R Dodge, Dawn M Elliott, Neil R Malhotra, Robert L Mauck, Lachlan J Smith
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Journal of Experimental Orthopaedics
Subjects:
Intervertebral disc degeneration
Inflammation
Interleukin‐1 receptor antagonist
PLGA microspheres
Rat
In vivo
Online Access:https://doi.org/10.1186/s40634-014-0015-8

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