Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster

Actin is an evolutionarily-conserved damage-associated molecular pattern that signals tissue injury in Drosophila melanogaster

Damage-associated molecular patterns (DAMPs) are molecules released by dead cells that trigger sterile inflammation and, in vertebrates, adaptive immunity. Actin is a DAMP detected in mammals by the receptor, DNGR-1, expressed by dendritic cells (DCs). DNGR-1 is phosphorylated by Src-family kinases...

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Bibliographic Details
Main Authors: Naren Srinivasan, Oliver Gordon, Susan Ahrens, Anna Franz, Safia Deddouche, Probir Chakravarty, David Phillips, Ali A Yunus, Michael K Rosen, Rita S Valente, Luis Teixeira, Barry Thompson, Marc S Dionne, Will Wood, Caetano Reis e Sousa
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
innate immunity
damage-associated molecular pattern
tissue injury
JAK/STAT pathway
DAMP
sterile inflammation
Online Access:https://elifesciences.org/articles/19662

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