Brain Versus Blood: A Systematic Review on the Concordance Between Peripheral and Central Kynurenine Pathway Measures in Psychiatric Disorders

Brain Versus Blood: A Systematic Review on the Concordance Between Peripheral and Central Kynurenine Pathway Measures in Psychiatric Disorders

ObjectiveDisturbances in the kynurenine pathway have been implicated in the pathophysiology of psychotic and mood disorders, as well as several other psychiatric illnesses. It remains uncertain however to what extent metabolite levels detectable in plasma or serum reflect brain kynurenine metabolism...

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Bibliographic Details
Main Authors: Katrien Skorobogatov, Livia De Picker, Robert Verkerk, Violette Coppens, Marion Leboyer, Norbert Müller, Manuel Morrens
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
kynurenine
blood-brain barrier
immune
tryptophan
psychiatry
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.716980/full

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