Analysis of the relationship between axial length, optic disc morphology, and regional variations in retinal vessel density in young adults with healthy eyes
PurposeTo investigate the relationship between optic disc morphology, axial length, and regional distribution of retinal vessels in healthy eyes of young adults.MethodsNine hundred and two healthy eyes were enrolled in this university-based, cross-sectional study. Spectral-domain optical coherence t...
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1280048/full |
| _version_ | 1797366770283053056 |
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| author | Yanhui Chen Yanhui Chen Hua Rong Yuling Liu Huijuan Gao Ziwen Sun Weiyu Dang Kunpeng Lu Baoyue Mi Jing Li Ruihua Wei |
| author_facet | Yanhui Chen Yanhui Chen Hua Rong Yuling Liu Huijuan Gao Ziwen Sun Weiyu Dang Kunpeng Lu Baoyue Mi Jing Li Ruihua Wei |
| author_sort | Yanhui Chen |
| collection | DOAJ |
| description | PurposeTo investigate the relationship between optic disc morphology, axial length, and regional distribution of retinal vessels in healthy eyes of young adults.MethodsNine hundred and two healthy eyes were enrolled in this university-based, cross-sectional study. Spectral-domain optical coherence tomography angiography was used to measure the parapapillary retinal vessel density. We automated the process of calculating optic disc tilt and rotation by using a program written in Python. Relationships between optic disc rotation, optic disc tilt, parapapillary vessel density, and other ocular parameters were analyzed using regression models.ResultsAs axial length increased, optic disc morphology became more tilted and rotated inferiorly. The superficial vessel density (SVD) and radial peripapillary capillary density (RPCD) gradually decreased in all regions except for the temporal quadrant. Increased temporal SVD (OR [95% CI] = 1.081 [1.039, 1.124], p < 0.001), reduced nasal SVD (OR [95% CI] = 0.898 [0.861, 0.937], p < 0.01), and short relative lens position (OR [95% CI] = 0.126 [0.032, 0.495], p = 0.003) were significantly associated with the presence of a tilted optic disc. Inferior disc rotation was associated with decreased superior deep vessel density (DVD) and increased inferior DVD and temporal DVD after adjusting for sex and axial length.ConclusionThe tilted and rotated optic discs were associated with the distribution of SVD and DVD, respectively. We should fully consider the influence of optic disc morphology on parapapillary vessel density in eyes with myopia. |
| first_indexed | 2024-03-08T17:08:27Z |
| format | Article |
| id | doaj.art-fe31b1aa6cbf4543a425c9678105d1ec |
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| language | English |
| last_indexed | 2024-03-08T17:08:27Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-fe31b1aa6cbf4543a425c9678105d1ec2024-01-04T04:17:28ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-01-011010.3389/fmed.2023.12800481280048Analysis of the relationship between axial length, optic disc morphology, and regional variations in retinal vessel density in young adults with healthy eyesYanhui Chen0Yanhui Chen1Hua Rong2Yuling Liu3Huijuan Gao4Ziwen Sun5Weiyu Dang6Kunpeng Lu7Baoyue Mi8Jing Li9Ruihua Wei10Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaTangshan Ophthalmic Hospital, Tangshan, Hebei, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaTianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, ChinaPurposeTo investigate the relationship between optic disc morphology, axial length, and regional distribution of retinal vessels in healthy eyes of young adults.MethodsNine hundred and two healthy eyes were enrolled in this university-based, cross-sectional study. Spectral-domain optical coherence tomography angiography was used to measure the parapapillary retinal vessel density. We automated the process of calculating optic disc tilt and rotation by using a program written in Python. Relationships between optic disc rotation, optic disc tilt, parapapillary vessel density, and other ocular parameters were analyzed using regression models.ResultsAs axial length increased, optic disc morphology became more tilted and rotated inferiorly. The superficial vessel density (SVD) and radial peripapillary capillary density (RPCD) gradually decreased in all regions except for the temporal quadrant. Increased temporal SVD (OR [95% CI] = 1.081 [1.039, 1.124], p < 0.001), reduced nasal SVD (OR [95% CI] = 0.898 [0.861, 0.937], p < 0.01), and short relative lens position (OR [95% CI] = 0.126 [0.032, 0.495], p = 0.003) were significantly associated with the presence of a tilted optic disc. Inferior disc rotation was associated with decreased superior deep vessel density (DVD) and increased inferior DVD and temporal DVD after adjusting for sex and axial length.ConclusionThe tilted and rotated optic discs were associated with the distribution of SVD and DVD, respectively. We should fully consider the influence of optic disc morphology on parapapillary vessel density in eyes with myopia.https://www.frontiersin.org/articles/10.3389/fmed.2023.1280048/fulloptic disc tiltoptic disc rotationmyopiaparapapillary retinal vessellens position |
| spellingShingle | Yanhui Chen Yanhui Chen Hua Rong Yuling Liu Huijuan Gao Ziwen Sun Weiyu Dang Kunpeng Lu Baoyue Mi Jing Li Ruihua Wei Analysis of the relationship between axial length, optic disc morphology, and regional variations in retinal vessel density in young adults with healthy eyes Frontiers in Medicine optic disc tilt optic disc rotation myopia parapapillary retinal vessel lens position |
| title | Analysis of the relationship between axial length, optic disc morphology, and regional variations in retinal vessel density in young adults with healthy eyes |
| title_full | Analysis of the relationship between axial length, optic disc morphology, and regional variations in retinal vessel density in young adults with healthy eyes |
| title_fullStr | Analysis of the relationship between axial length, optic disc morphology, and regional variations in retinal vessel density in young adults with healthy eyes |
| title_full_unstemmed | Analysis of the relationship between axial length, optic disc morphology, and regional variations in retinal vessel density in young adults with healthy eyes |
| title_short | Analysis of the relationship between axial length, optic disc morphology, and regional variations in retinal vessel density in young adults with healthy eyes |
| title_sort | analysis of the relationship between axial length optic disc morphology and regional variations in retinal vessel density in young adults with healthy eyes |
| topic | optic disc tilt optic disc rotation myopia parapapillary retinal vessel lens position |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1280048/full |
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