Humanized Mouse Models of Staphylococcus aureus Infection
Staphylococcus aureus is a successful human pathogen that has adapted itself in response to selection pressure by the human immune system. A commensal of the human skin and nose, it is a leading cause of several conditions: skin and soft tissue infection, pneumonia, septicemia, peritonitis, bacterem...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00512/full |
| _version_ | 1828770474962714624 |
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| author | Dane Parker |
| author_facet | Dane Parker |
| author_sort | Dane Parker |
| collection | DOAJ |
| description | Staphylococcus aureus is a successful human pathogen that has adapted itself in response to selection pressure by the human immune system. A commensal of the human skin and nose, it is a leading cause of several conditions: skin and soft tissue infection, pneumonia, septicemia, peritonitis, bacteremia, and endocarditis. Mice have been used extensively in all these conditions to identify virulence factors and host components important for pathogenesis. Although significant effort has gone toward development of an anti-staphylococcal vaccine, antibodies have proven ineffective in preventing infection in humans after successful studies in mice. These results have raised questions as to the utility of mice to predict patient outcome and suggest that humanized mice might prove useful in modeling infection. The development of humanized mouse models of S. aureus infection will allow us to assess the contribution of several human-specific virulence factors, in addition to exploring components of the human immune system in protection against S. aureus infection. Their use is discussed in light of several recently reported studies. |
| first_indexed | 2024-12-11T14:07:00Z |
| format | Article |
| id | doaj.art-fe3225994cb9406e865bd0656e915dfe |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T14:07:00Z |
| publishDate | 2017-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-fe3225994cb9406e865bd0656e915dfe2022-12-22T01:03:37ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-05-01810.3389/fimmu.2017.00512266567Humanized Mouse Models of Staphylococcus aureus InfectionDane Parker0Department of Pediatrics, Columbia University, New York, NY, USAStaphylococcus aureus is a successful human pathogen that has adapted itself in response to selection pressure by the human immune system. A commensal of the human skin and nose, it is a leading cause of several conditions: skin and soft tissue infection, pneumonia, septicemia, peritonitis, bacteremia, and endocarditis. Mice have been used extensively in all these conditions to identify virulence factors and host components important for pathogenesis. Although significant effort has gone toward development of an anti-staphylococcal vaccine, antibodies have proven ineffective in preventing infection in humans after successful studies in mice. These results have raised questions as to the utility of mice to predict patient outcome and suggest that humanized mice might prove useful in modeling infection. The development of humanized mouse models of S. aureus infection will allow us to assess the contribution of several human-specific virulence factors, in addition to exploring components of the human immune system in protection against S. aureus infection. Their use is discussed in light of several recently reported studies.http://journal.frontiersin.org/article/10.3389/fimmu.2017.00512/fullStaphylococcus aureushumanized mousepneumonialungsepsisskin |
| spellingShingle | Dane Parker Humanized Mouse Models of Staphylococcus aureus Infection Frontiers in Immunology Staphylococcus aureus humanized mouse pneumonia lung sepsis skin |
| title | Humanized Mouse Models of Staphylococcus aureus Infection |
| title_full | Humanized Mouse Models of Staphylococcus aureus Infection |
| title_fullStr | Humanized Mouse Models of Staphylococcus aureus Infection |
| title_full_unstemmed | Humanized Mouse Models of Staphylococcus aureus Infection |
| title_short | Humanized Mouse Models of Staphylococcus aureus Infection |
| title_sort | humanized mouse models of staphylococcus aureus infection |
| topic | Staphylococcus aureus humanized mouse pneumonia lung sepsis skin |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00512/full |
| work_keys_str_mv | AT daneparker humanizedmousemodelsofstaphylococcusaureusinfection |