Floating Microballoons of Rhynchosia densiflora Leaf Extract for the Treatment of Peptic Ulcer
Peptic ulcer is one of the most common gastrointestinal problems diagnosed all over the world. The aim of the present study is to develop floating microballoons of Rhynchosia densiflora (Roth) DC leaf extract and to evaluate its peptic ulcer activity. An ethanolic extract of R. densiflora (Roth) DC...
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| Format: | Article |
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Shiraz University of Medical Sciences
2022-03-01
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| Series: | Trends in Pharmaceutical Sciences |
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| Online Access: | https://tips.sums.ac.ir/article_48015_560be8f7e31588705512138cb9e2f32a.pdf |
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| author | Devadath NG Ashoka Babu VL Basavaraj BV Mohammad Azamthulla |
| author_facet | Devadath NG Ashoka Babu VL Basavaraj BV Mohammad Azamthulla |
| author_sort | Devadath NG |
| collection | DOAJ |
| description | Peptic ulcer is one of the most common gastrointestinal problems diagnosed all over the world. The aim of the present study is to develop floating microballoons of Rhynchosia densiflora (Roth) DC leaf extract and to evaluate its peptic ulcer activity. An ethanolic extract of R. densiflora (Roth) DC leaves was prepared by Soxhlet extraction and subjected to phytochemical analysis. Microballoons loaded with ethanolic extract of R. densiflora leaf were developed by solvent evaporation method and characterized by optical microscopy, floating time, and release characteristics. Acute oral toxicity study of microballons was carried out following OECD guidelines 423 and antiulcer activity was performed by pylorus ligation, indomethacin and cystamine induced duodenal ulcer methods. R. densiflora extract was found to contain glycosides, proteins, flavonoids, phenolic compounds, tannins and saponins. The particle size of microballoons of R. densiflora extract was found to be in the range of 300 μm. Acute toxicity studies of microballoons did not produce any toxic symptoms and mortality in animals, hence 100 and 200 mg/kg concentrations were selected to screen antiulcer activity. Both the doses showed significant gastric ulcer healing effect and gastric antisecretory effect in pylorus ligated rats, gastric cytoprotective effect in indomethacin induced gastric ulcer and also produced a significant reduction in duodenal ulcers. Dose of 200 mg/kg showed highly significant antiulcer activity than 100 mg/kg. Thus, it is concluded that floating microballoons loaded with R. densiflora extract significantly reduced gastric acid secretion, increased healing of gastric ulcers and also prevent the duodenal ulcers in rats.
Please cite this article as: Devadath NG, Ashoka Babu VL, Basavaraj BV, Mohammad Azamthulla. Floating Microballoons for the treatment of Peptic Ulcer. Trends in Pharmaceutical Sciences. 2022;8(1):25-36.
doi: 10.30476/TIPS.2021.93365.1124 |
| first_indexed | 2024-04-13T09:36:11Z |
| format | Article |
| id | doaj.art-fe3234007c1c494d98f50190587a627c |
| institution | Directory Open Access Journal |
| issn | 2423-5652 |
| language | English |
| last_indexed | 2024-04-13T09:36:11Z |
| publishDate | 2022-03-01 |
| publisher | Shiraz University of Medical Sciences |
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| series | Trends in Pharmaceutical Sciences |
| spelling | doaj.art-fe3234007c1c494d98f50190587a627c2022-12-22T02:52:06ZengShiraz University of Medical SciencesTrends in Pharmaceutical Sciences2423-56522022-03-0181253610.30476/tips.2021.93365.112448015Floating Microballoons of Rhynchosia densiflora Leaf Extract for the Treatment of Peptic UlcerDevadath NG0Ashoka Babu VL1Basavaraj BV2Mohammad Azamthulla3Department of Pharmacology, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Bengaluru-560054, India.Department of Pharmacognosy, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Bengaluru-560054, India.Department of Pharmaceutics, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Bengaluru-560054, India.Department of Pharmacology, Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Bengaluru-560054, India.Peptic ulcer is one of the most common gastrointestinal problems diagnosed all over the world. The aim of the present study is to develop floating microballoons of Rhynchosia densiflora (Roth) DC leaf extract and to evaluate its peptic ulcer activity. An ethanolic extract of R. densiflora (Roth) DC leaves was prepared by Soxhlet extraction and subjected to phytochemical analysis. Microballoons loaded with ethanolic extract of R. densiflora leaf were developed by solvent evaporation method and characterized by optical microscopy, floating time, and release characteristics. Acute oral toxicity study of microballons was carried out following OECD guidelines 423 and antiulcer activity was performed by pylorus ligation, indomethacin and cystamine induced duodenal ulcer methods. R. densiflora extract was found to contain glycosides, proteins, flavonoids, phenolic compounds, tannins and saponins. The particle size of microballoons of R. densiflora extract was found to be in the range of 300 μm. Acute toxicity studies of microballoons did not produce any toxic symptoms and mortality in animals, hence 100 and 200 mg/kg concentrations were selected to screen antiulcer activity. Both the doses showed significant gastric ulcer healing effect and gastric antisecretory effect in pylorus ligated rats, gastric cytoprotective effect in indomethacin induced gastric ulcer and also produced a significant reduction in duodenal ulcers. Dose of 200 mg/kg showed highly significant antiulcer activity than 100 mg/kg. Thus, it is concluded that floating microballoons loaded with R. densiflora extract significantly reduced gastric acid secretion, increased healing of gastric ulcers and also prevent the duodenal ulcers in rats. Please cite this article as: Devadath NG, Ashoka Babu VL, Basavaraj BV, Mohammad Azamthulla. Floating Microballoons for the treatment of Peptic Ulcer. Trends in Pharmaceutical Sciences. 2022;8(1):25-36. doi: 10.30476/TIPS.2021.93365.1124https://tips.sums.ac.ir/article_48015_560be8f7e31588705512138cb9e2f32a.pdfpeptic ulcermicrospheresrhynchosia densiflora (roth) dcpylorus ligationgastric acidantiulcer agents |
| spellingShingle | Devadath NG Ashoka Babu VL Basavaraj BV Mohammad Azamthulla Floating Microballoons of Rhynchosia densiflora Leaf Extract for the Treatment of Peptic Ulcer Trends in Pharmaceutical Sciences peptic ulcer microspheres rhynchosia densiflora (roth) dc pylorus ligation gastric acid antiulcer agents |
| title | Floating Microballoons of Rhynchosia densiflora Leaf Extract for the Treatment of Peptic Ulcer |
| title_full | Floating Microballoons of Rhynchosia densiflora Leaf Extract for the Treatment of Peptic Ulcer |
| title_fullStr | Floating Microballoons of Rhynchosia densiflora Leaf Extract for the Treatment of Peptic Ulcer |
| title_full_unstemmed | Floating Microballoons of Rhynchosia densiflora Leaf Extract for the Treatment of Peptic Ulcer |
| title_short | Floating Microballoons of Rhynchosia densiflora Leaf Extract for the Treatment of Peptic Ulcer |
| title_sort | floating microballoons of rhynchosia densiflora leaf extract for the treatment of peptic ulcer |
| topic | peptic ulcer microspheres rhynchosia densiflora (roth) dc pylorus ligation gastric acid antiulcer agents |
| url | https://tips.sums.ac.ir/article_48015_560be8f7e31588705512138cb9e2f32a.pdf |
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