High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain
Background: We evaluated whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without DFS and with non-diabetic subjects. Methods: Retrospective, observational study...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/7/1368 |
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| author | Montserrat Dòria Àngels Betriu Montserrat Belart Verónica Rosado Marta Hernández Felipe Sarro Jordi Real Esmeralda Castelblanco Linda Roxana Pacheco Elvira Fernández Josep Franch-Nadal Mònica Gratacòs Dídac Mauricio |
| author_facet | Montserrat Dòria Àngels Betriu Montserrat Belart Verónica Rosado Marta Hernández Felipe Sarro Jordi Real Esmeralda Castelblanco Linda Roxana Pacheco Elvira Fernández Josep Franch-Nadal Mònica Gratacòs Dídac Mauricio |
| author_sort | Montserrat Dòria |
| collection | DOAJ |
| description | Background: We evaluated whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without DFS and with non-diabetic subjects. Methods: Retrospective, observational study in 220 subjects followed for six years. We calculated and compared the frequency and 5-year cumulative incidence of all-cause mortality, cardiovascular (CV) mortality, CV events, major adverse CV events (MACE), and new foot ulcer (FU) or amputation. We also examined prognostic factors of all-cause and CV mortality based on baseline characteristics. Results: DM patients had a 1.98 times higher probability of all-cause mortality than those without DM (<i>p</i> = 0.001) and 2.42 times higher likelihood of CV mortality and new FU or amputation (<i>p</i> = 0.002 and <i>p</i> = 0.008, respectively). In the DM cohort, only the risk of a new FU or amputation was 2.69 times higher among those with previous DFS (<i>p</i> = 0.021). In patients with DM, older age was the only predictor of all-cause and CV mortality (<i>p</i> = 0.001 and <i>p</i> = 0.014, respectively). Conclusions: Although all-cause and CV mortality were increased on HD subjects with DM, the presence of DFS did not modify the excess risk. Additional studies are warranted to further explore the impact of DFS in subjects with DM undergoing HD. |
| first_indexed | 2024-03-10T12:52:49Z |
| format | Article |
| id | doaj.art-fe3352b143634f229922a10f9d50d5fb |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T12:52:49Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-fe3352b143634f229922a10f9d50d5fb2023-11-21T12:59:59ZengMDPI AGJournal of Clinical Medicine2077-03832021-03-01107136810.3390/jcm10071368High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, SpainMontserrat Dòria0Àngels Betriu1Montserrat Belart2Verónica Rosado3Marta Hernández4Felipe Sarro5Jordi Real6Esmeralda Castelblanco7Linda Roxana Pacheco8Elvira Fernández9Josep Franch-Nadal10Mònica Gratacòs11Dídac Mauricio12Department of Endocrinology & Nutrition, University Hospital Arnau de Vilanova and Santa Maria, 25198 Lleida, SpainSistemes Renals, 2508 Lleida, SpainSistemes Renals, 2508 Lleida, SpainDepartment of Endocrinology & Nutrition, University Hospital Arnau de Vilanova and Santa Maria, 25198 Lleida, SpainDepartment of Endocrinology & Nutrition, University Hospital Arnau de Vilanova and Santa Maria, 25198 Lleida, SpainDepartment of Nephrology, University Hospital Arnau de Vilanova and Santa Maria, 25198 Lleida, SpainDAP-Cat group, Unitat de Suport a la Recerca Barcelona, Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08006 Barcelona, SpainDAP-Cat group, Unitat de Suport a la Recerca Barcelona, Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08006 Barcelona, SpainDepartment of Endocrinology & Nutrition, University Hospital Arnau de Vilanova and Santa Maria, 25198 Lleida, SpainLleida Institute for Biomedical Research Dr. Pifarré Foundation IRBLleida, University of Lleida, 25198 Lleida, SpainDAP-Cat group, Unitat de Suport a la Recerca Barcelona, Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08006 Barcelona, SpainDAP-Cat group, Unitat de Suport a la Recerca Barcelona, Fundació Institut Universitari per a la recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08006 Barcelona, SpainDepartment of Endocrinology and Nutrition, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, 08041 Barcelona, SpainBackground: We evaluated whether, in subjects receiving haemodialysis (HD), the presence of diabetic foot syndrome (DFS) was associated with increased mortality compared with subjects with diabetes mellitus (DM) without DFS and with non-diabetic subjects. Methods: Retrospective, observational study in 220 subjects followed for six years. We calculated and compared the frequency and 5-year cumulative incidence of all-cause mortality, cardiovascular (CV) mortality, CV events, major adverse CV events (MACE), and new foot ulcer (FU) or amputation. We also examined prognostic factors of all-cause and CV mortality based on baseline characteristics. Results: DM patients had a 1.98 times higher probability of all-cause mortality than those without DM (<i>p</i> = 0.001) and 2.42 times higher likelihood of CV mortality and new FU or amputation (<i>p</i> = 0.002 and <i>p</i> = 0.008, respectively). In the DM cohort, only the risk of a new FU or amputation was 2.69 times higher among those with previous DFS (<i>p</i> = 0.021). In patients with DM, older age was the only predictor of all-cause and CV mortality (<i>p</i> = 0.001 and <i>p</i> = 0.014, respectively). Conclusions: Although all-cause and CV mortality were increased on HD subjects with DM, the presence of DFS did not modify the excess risk. Additional studies are warranted to further explore the impact of DFS in subjects with DM undergoing HD.https://www.mdpi.com/2077-0383/10/7/1368diabetes mellitushaemodialysisdiabetic foot syndromefoot ulceramputationall-cause mortality |
| spellingShingle | Montserrat Dòria Àngels Betriu Montserrat Belart Verónica Rosado Marta Hernández Felipe Sarro Jordi Real Esmeralda Castelblanco Linda Roxana Pacheco Elvira Fernández Josep Franch-Nadal Mònica Gratacòs Dídac Mauricio High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain Journal of Clinical Medicine diabetes mellitus haemodialysis diabetic foot syndrome foot ulcer amputation all-cause mortality |
| title | High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain |
| title_full | High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain |
| title_fullStr | High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain |
| title_full_unstemmed | High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain |
| title_short | High Incidence of Adverse Outcomes in Haemodialysis Patients with Diabetes with or without Diabetic Foot Syndrome: A 5-Year Observational Study in Lleida, Spain |
| title_sort | high incidence of adverse outcomes in haemodialysis patients with diabetes with or without diabetic foot syndrome a 5 year observational study in lleida spain |
| topic | diabetes mellitus haemodialysis diabetic foot syndrome foot ulcer amputation all-cause mortality |
| url | https://www.mdpi.com/2077-0383/10/7/1368 |
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