Effect of Infarct Location and Size on Left Atrial Function: A Cardiovascular Magnetic Resonance Feature Tracking Study
Background: LA function has been recognized as a significant prognostic marker in many cardiovascular diseases. Cardiovascular magnetic resonance feature tracking (CMR-FT) represents a promising technique for left atrial function evaluation. The size and location of myocardial infarction are importa...
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MDPI AG
2022-11-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/23/6938 |
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| author | He Zhang Zhaoxin Tian Huaibi Huo Han Li Hui Liu Yang Hou Xu Dai Ting Liu Shiqi Jin |
| author_facet | He Zhang Zhaoxin Tian Huaibi Huo Han Li Hui Liu Yang Hou Xu Dai Ting Liu Shiqi Jin |
| author_sort | He Zhang |
| collection | DOAJ |
| description | Background: LA function has been recognized as a significant prognostic marker in many cardiovascular diseases. Cardiovascular magnetic resonance feature tracking (CMR-FT) represents a promising technique for left atrial function evaluation. The size and location of myocardial infarction are important factors in the cause of adverse left ventricular remodeling, but the effect on the left atriam is unclear. Purpose: to investigate the effect of location and size of previous myocardial infarction (MI) on LA function using CMR-FT. Study type: retrospective. Population: patients formerly diagnosed with anterior MI (<i>n</i> = 42) or non-anterior MI (<i>n</i> = 40) and healthy controls (<i>n</i> = 47). Field Strength/Sequence: a 3.0T MR, Steady state free precession (SSFP), Phase-sensitive inversion recovery (PSIR). Assessment: infarct location and size were assigned and quantified by late-gadolinium enhancement (LGE) imaging. LA performance was analyzed using CMR-FT in 2- and 4-chamber cine images, including LA reservoir, conduit and booster pump function. Statistics: descriptive statistics, ANOVA with post Bonferroni correction, Kruskal–Wallis H, Spearman’s correlation, intraclass correlation coefficient. Results: Anterior MI patients had impaired LA reservoir function (LATEF, εs, SRs), conduit function (LAPEF, εe, SRs) and booster pump function (LAAEF, εa) compared with controls (<i>p</i> < 0.05). Non-anterior MI patients had impaired LA strain (εs, εe, εa; <i>p</i> < 0.05) but preserved LAEFs (<i>p</i> > 0.05). After adjusting the area of MI, there was no significant difference in the LA morphology and function between the anterior and non-anterior wall groups. Stratification analysis by MI size revealed that LA volumes and LAEFs were unchanged in patients with MI size ≤ 15% compared with controls (<i>p</i> > 0.05); only εs and εe were decreased (<i>p</i> < 0.05). Increased LAVIpre-a, LAVImin and decreased LATEF, and LAAEF were found in patients with MI size > 15% compared with the MI size ≤ 15% group (<i>p</i> < 0.05). LVSVI, εs and MI size were significant correlated with LAVI pre-a in multiple stepwise regression analysis. Data conclusions: The location of myocardial infarction is not a major factor affecting the morphology and function of the left atrium. Patients with MI size > 15% experience more pronounced post-infarction LA remodeling and dysfunction than MI size ≤ 15% patients. |
| first_indexed | 2024-03-09T17:44:07Z |
| format | Article |
| id | doaj.art-fe3366c7c5e447ab8aca369c6794ba47 |
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| language | English |
| last_indexed | 2024-03-09T17:44:07Z |
| publishDate | 2022-11-01 |
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| spelling | doaj.art-fe3366c7c5e447ab8aca369c6794ba472023-11-24T11:20:14ZengMDPI AGJournal of Clinical Medicine2077-03832022-11-011123693810.3390/jcm11236938Effect of Infarct Location and Size on Left Atrial Function: A Cardiovascular Magnetic Resonance Feature Tracking StudyHe Zhang0Zhaoxin Tian1Huaibi Huo2Han Li3Hui Liu4Yang Hou5Xu Dai6Ting Liu7Shiqi Jin8Department of Radiology, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Radiology, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Radiology, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Radiology, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Radiology, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Radiology, Shengjing Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Radiology, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Radiology, The First Hospital of China Medical University, Shenyang 110001, ChinaDepartment of Radiology, The First Hospital of China Medical University, Shenyang 110001, ChinaBackground: LA function has been recognized as a significant prognostic marker in many cardiovascular diseases. Cardiovascular magnetic resonance feature tracking (CMR-FT) represents a promising technique for left atrial function evaluation. The size and location of myocardial infarction are important factors in the cause of adverse left ventricular remodeling, but the effect on the left atriam is unclear. Purpose: to investigate the effect of location and size of previous myocardial infarction (MI) on LA function using CMR-FT. Study type: retrospective. Population: patients formerly diagnosed with anterior MI (<i>n</i> = 42) or non-anterior MI (<i>n</i> = 40) and healthy controls (<i>n</i> = 47). Field Strength/Sequence: a 3.0T MR, Steady state free precession (SSFP), Phase-sensitive inversion recovery (PSIR). Assessment: infarct location and size were assigned and quantified by late-gadolinium enhancement (LGE) imaging. LA performance was analyzed using CMR-FT in 2- and 4-chamber cine images, including LA reservoir, conduit and booster pump function. Statistics: descriptive statistics, ANOVA with post Bonferroni correction, Kruskal–Wallis H, Spearman’s correlation, intraclass correlation coefficient. Results: Anterior MI patients had impaired LA reservoir function (LATEF, εs, SRs), conduit function (LAPEF, εe, SRs) and booster pump function (LAAEF, εa) compared with controls (<i>p</i> < 0.05). Non-anterior MI patients had impaired LA strain (εs, εe, εa; <i>p</i> < 0.05) but preserved LAEFs (<i>p</i> > 0.05). After adjusting the area of MI, there was no significant difference in the LA morphology and function between the anterior and non-anterior wall groups. Stratification analysis by MI size revealed that LA volumes and LAEFs were unchanged in patients with MI size ≤ 15% compared with controls (<i>p</i> > 0.05); only εs and εe were decreased (<i>p</i> < 0.05). Increased LAVIpre-a, LAVImin and decreased LATEF, and LAAEF were found in patients with MI size > 15% compared with the MI size ≤ 15% group (<i>p</i> < 0.05). LVSVI, εs and MI size were significant correlated with LAVI pre-a in multiple stepwise regression analysis. Data conclusions: The location of myocardial infarction is not a major factor affecting the morphology and function of the left atrium. Patients with MI size > 15% experience more pronounced post-infarction LA remodeling and dysfunction than MI size ≤ 15% patients.https://www.mdpi.com/2077-0383/11/23/6938cardiac magnetic resonancefeature trackingmyocardial infarctionleft atrial dysfunction |
| spellingShingle | He Zhang Zhaoxin Tian Huaibi Huo Han Li Hui Liu Yang Hou Xu Dai Ting Liu Shiqi Jin Effect of Infarct Location and Size on Left Atrial Function: A Cardiovascular Magnetic Resonance Feature Tracking Study Journal of Clinical Medicine cardiac magnetic resonance feature tracking myocardial infarction left atrial dysfunction |
| title | Effect of Infarct Location and Size on Left Atrial Function: A Cardiovascular Magnetic Resonance Feature Tracking Study |
| title_full | Effect of Infarct Location and Size on Left Atrial Function: A Cardiovascular Magnetic Resonance Feature Tracking Study |
| title_fullStr | Effect of Infarct Location and Size on Left Atrial Function: A Cardiovascular Magnetic Resonance Feature Tracking Study |
| title_full_unstemmed | Effect of Infarct Location and Size on Left Atrial Function: A Cardiovascular Magnetic Resonance Feature Tracking Study |
| title_short | Effect of Infarct Location and Size on Left Atrial Function: A Cardiovascular Magnetic Resonance Feature Tracking Study |
| title_sort | effect of infarct location and size on left atrial function a cardiovascular magnetic resonance feature tracking study |
| topic | cardiac magnetic resonance feature tracking myocardial infarction left atrial dysfunction |
| url | https://www.mdpi.com/2077-0383/11/23/6938 |
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