Supplementation of bone marrow aspirate-derived platelet-rich plasma for treating radiation-induced ulcer after cardiac fluoroscopic procedures: A preliminary report
Background: The frequency of encountering radiodermatitis caused by X-ray fluoroscopic procedures for ischaemic heart disease is increasing. In severe cases, devastating ulcers with pain, for which conservative therapy is ineffective, emerge. Radiation-induced ulcers are notorious for being difficul...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical Publishers, Inc.
2012-01-01
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| Series: | Indian Journal of Plastic Surgery |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/0970-0358.96599 |
| _version_ | 1830430874424836096 |
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| author | Soh Nishimoto Kenji Fukuda Kenichiro Kawai Toshihiro Fujiwara Tomoko Tsumano Kazutoshi Fujita Masao Kakibuchi |
| author_facet | Soh Nishimoto Kenji Fukuda Kenichiro Kawai Toshihiro Fujiwara Tomoko Tsumano Kazutoshi Fujita Masao Kakibuchi |
| author_sort | Soh Nishimoto |
| collection | DOAJ |
| description | Background: The frequency of encountering radiodermatitis caused by X-ray fluoroscopic procedures for ischaemic heart disease is increasing. In severe cases, devastating ulcers with pain, for which conservative therapy is ineffective, emerge. Radiation-induced ulcers are notorious for being difficult to treat. Simple skin grafting often fails because of the poor state of the wound bed. A vascularized flap is a very good option. However, the non-adherence of the well-vascularized flap with the irradiated wound bed is frequently experienced. Aim: To ameliorate the irradiated wound bed, bone marrow-derived platelet-rich plasma (bm-PRP) was delivered during the surgery. Materials and Methods: Four patients with severe cutaneous radiation injury accompanied by unbearable pain after multiple fluoroscopic procedures for ischaemic heart disease were treated. Wide excision of the lesion and coverage with a skin flap supplemented with bm-PRP injection was performed. Results: All patients obtained wound closure and were relieved from pain. No complication concerning the bone marrow aspiration and delivery of bm-PRP was observed. Conclusions: Supplementation of bm-PRP can be an option without major complications, time, and cost to improve the surgical outcome for irradiated wounds. |
| first_indexed | 2024-12-21T01:57:39Z |
| format | Article |
| id | doaj.art-fe33fde64a91409c9a13b2540404d500 |
| institution | Directory Open Access Journal |
| issn | 0970-0358 1998-376X |
| language | English |
| last_indexed | 2024-12-21T01:57:39Z |
| publishDate | 2012-01-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | Indian Journal of Plastic Surgery |
| spelling | doaj.art-fe33fde64a91409c9a13b2540404d5002022-12-21T19:19:44ZengThieme Medical Publishers, Inc.Indian Journal of Plastic Surgery0970-03581998-376X2012-01-01450110911410.4103/0970-0358.96599Supplementation of bone marrow aspirate-derived platelet-rich plasma for treating radiation-induced ulcer after cardiac fluoroscopic procedures: A preliminary reportSoh Nishimoto0Kenji Fukuda1Kenichiro Kawai2Toshihiro Fujiwara3Tomoko Tsumano4Kazutoshi Fujita5Masao Kakibuchi6Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanDepartment of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanDepartment of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanDepartment of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanDepartment of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanDepartment of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanDepartment of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, JapanBackground: The frequency of encountering radiodermatitis caused by X-ray fluoroscopic procedures for ischaemic heart disease is increasing. In severe cases, devastating ulcers with pain, for which conservative therapy is ineffective, emerge. Radiation-induced ulcers are notorious for being difficult to treat. Simple skin grafting often fails because of the poor state of the wound bed. A vascularized flap is a very good option. However, the non-adherence of the well-vascularized flap with the irradiated wound bed is frequently experienced. Aim: To ameliorate the irradiated wound bed, bone marrow-derived platelet-rich plasma (bm-PRP) was delivered during the surgery. Materials and Methods: Four patients with severe cutaneous radiation injury accompanied by unbearable pain after multiple fluoroscopic procedures for ischaemic heart disease were treated. Wide excision of the lesion and coverage with a skin flap supplemented with bm-PRP injection was performed. Results: All patients obtained wound closure and were relieved from pain. No complication concerning the bone marrow aspiration and delivery of bm-PRP was observed. Conclusions: Supplementation of bm-PRP can be an option without major complications, time, and cost to improve the surgical outcome for irradiated wounds.http://www.thieme-connect.de/DOI/DOI?10.4103/0970-0358.96599bone marrowcardiac fluoroscopyplatelet-rich plasmaradiation ulcerskin flap |
| spellingShingle | Soh Nishimoto Kenji Fukuda Kenichiro Kawai Toshihiro Fujiwara Tomoko Tsumano Kazutoshi Fujita Masao Kakibuchi Supplementation of bone marrow aspirate-derived platelet-rich plasma for treating radiation-induced ulcer after cardiac fluoroscopic procedures: A preliminary report Indian Journal of Plastic Surgery bone marrow cardiac fluoroscopy platelet-rich plasma radiation ulcer skin flap |
| title | Supplementation of bone marrow aspirate-derived platelet-rich plasma for treating radiation-induced ulcer after cardiac fluoroscopic procedures: A preliminary report |
| title_full | Supplementation of bone marrow aspirate-derived platelet-rich plasma for treating radiation-induced ulcer after cardiac fluoroscopic procedures: A preliminary report |
| title_fullStr | Supplementation of bone marrow aspirate-derived platelet-rich plasma for treating radiation-induced ulcer after cardiac fluoroscopic procedures: A preliminary report |
| title_full_unstemmed | Supplementation of bone marrow aspirate-derived platelet-rich plasma for treating radiation-induced ulcer after cardiac fluoroscopic procedures: A preliminary report |
| title_short | Supplementation of bone marrow aspirate-derived platelet-rich plasma for treating radiation-induced ulcer after cardiac fluoroscopic procedures: A preliminary report |
| title_sort | supplementation of bone marrow aspirate derived platelet rich plasma for treating radiation induced ulcer after cardiac fluoroscopic procedures a preliminary report |
| topic | bone marrow cardiac fluoroscopy platelet-rich plasma radiation ulcer skin flap |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/0970-0358.96599 |
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