HLA-DR Helps to Differentiate Erythrodermic Cutaneous T-cell Lymphoma from Erythrodermic Inflammatory Dermatoses in Flow Cytometry
Differential diagnosis of erythroderma is challenging in dermatology, especially in differentiating erythrodermic cutaneous T-cell lymphoma from erythrodermic inflammatory dermatoses. This study retrospectively reviewed the peripheral blood flow cytometric results of 73 patients diagnosed with eryth...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2023-08-01
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| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: | https://medicaljournalssweden.se/actadv/article/view/5668 |
| _version_ | 1827888784631398400 |
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| author | Jingru Sun Ran You Beini Lyu Xueying Li Yumei Gao Yujie Wen Chenxue Qu Yang Wang |
| author_facet | Jingru Sun Ran You Beini Lyu Xueying Li Yumei Gao Yujie Wen Chenxue Qu Yang Wang |
| author_sort | Jingru Sun |
| collection | DOAJ |
| description | Differential diagnosis of erythroderma is challenging in dermatology, especially in differentiating erythrodermic cutaneous T-cell lymphoma from erythrodermic inflammatory dermatoses. This study retrospectively reviewed the peripheral blood flow cytometric results of 73 patients diagnosed with erythroderma at Peking University First Hospital from 2014 to 2019. The flow cytometry antibody panel included white blood cell markers, T-cell markers, B-cell markers, T-cell activation markers, and T helper cell differentiation markers. Features of the cell surface antigens were compared between 34 patients with erythrodermic cutaneous T-cell lymphoma and 39 patients with erythrodermic inflammatory dermatoses. The percentage of HLA-DR+/CD4+T cells was the most pronounced marker to distinguish erythrodermic cutaneous T-cell lymphoma from erythrodermic inflammatory dermatoses, with a threshold of 20.85% (sensitivity 96.77%, specificity 70.37%, p = 0.000, area under the curve (AUC) 0.882), suggesting its potential capability in the differential diagnosis of erythrodermic cutaneous T-cell lymphoma from erythrodermic inflammatory dermatoses. Moreover, in contrast to erythrodermic inflammatory dermatoses, the percentage of Th17 cells was significantly downregulated in erythrodermic cutaneous T-cell lymphoma (p = 0.001), demonstrating a dysregulated immune environment in erythrodermic cutaneous T-cell lymphoma.
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| first_indexed | 2024-03-12T20:38:44Z |
| format | Article |
| id | doaj.art-fe3428f8fa5e4c08a9eac89e4066fd7a |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-03-12T20:38:44Z |
| publishDate | 2023-08-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-fe3428f8fa5e4c08a9eac89e4066fd7a2023-08-01T11:39:33ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572023-08-0110310.2340/actadv.v103.5668HLA-DR Helps to Differentiate Erythrodermic Cutaneous T-cell Lymphoma from Erythrodermic Inflammatory Dermatoses in Flow CytometryJingru Sun0Ran You1Beini Lyu2Xueying Li3Yumei Gao4Yujie Wen5Chenxue Qu6Yang Wang7Department of Dermatology and Venereology, Peking University First Hospital, Beijing 100034, ChinaDepartment of Clinical Laboratory, Peking University First Hospital, Beijing 100034, ChinaPeking University Institute for Global Health and Development, Beijing, ChinaDepartment of Biostatistics, Peking University First Hospital, Beijing 100034, ChinaDepartment of Dermatology and Venereology, Peking University First Hospital, Beijing 100034, ChinaDepartment of Dermatology and Venereology, Peking University First Hospital, Beijing 100034, ChinaDepartment of Clinical Laboratory, Peking University First Hospital, Beijing 100034, ChinaDepartment of Dermatology and Venereology, Peking University First Hospital, Beijing 100034, ChinaDifferential diagnosis of erythroderma is challenging in dermatology, especially in differentiating erythrodermic cutaneous T-cell lymphoma from erythrodermic inflammatory dermatoses. This study retrospectively reviewed the peripheral blood flow cytometric results of 73 patients diagnosed with erythroderma at Peking University First Hospital from 2014 to 2019. The flow cytometry antibody panel included white blood cell markers, T-cell markers, B-cell markers, T-cell activation markers, and T helper cell differentiation markers. Features of the cell surface antigens were compared between 34 patients with erythrodermic cutaneous T-cell lymphoma and 39 patients with erythrodermic inflammatory dermatoses. The percentage of HLA-DR+/CD4+T cells was the most pronounced marker to distinguish erythrodermic cutaneous T-cell lymphoma from erythrodermic inflammatory dermatoses, with a threshold of 20.85% (sensitivity 96.77%, specificity 70.37%, p = 0.000, area under the curve (AUC) 0.882), suggesting its potential capability in the differential diagnosis of erythrodermic cutaneous T-cell lymphoma from erythrodermic inflammatory dermatoses. Moreover, in contrast to erythrodermic inflammatory dermatoses, the percentage of Th17 cells was significantly downregulated in erythrodermic cutaneous T-cell lymphoma (p = 0.001), demonstrating a dysregulated immune environment in erythrodermic cutaneous T-cell lymphoma. https://medicaljournalssweden.se/actadv/article/view/5668Erythrodermaerythrodermic cutaneous T-cell lymphomaerythrodermic inflammatory dermatosesflow cytometryHLA-DRT helper 17 cells |
| spellingShingle | Jingru Sun Ran You Beini Lyu Xueying Li Yumei Gao Yujie Wen Chenxue Qu Yang Wang HLA-DR Helps to Differentiate Erythrodermic Cutaneous T-cell Lymphoma from Erythrodermic Inflammatory Dermatoses in Flow Cytometry Acta Dermato-Venereologica Erythroderma erythrodermic cutaneous T-cell lymphoma erythrodermic inflammatory dermatoses flow cytometry HLA-DR T helper 17 cells |
| title | HLA-DR Helps to Differentiate Erythrodermic Cutaneous T-cell Lymphoma from Erythrodermic Inflammatory Dermatoses in Flow Cytometry |
| title_full | HLA-DR Helps to Differentiate Erythrodermic Cutaneous T-cell Lymphoma from Erythrodermic Inflammatory Dermatoses in Flow Cytometry |
| title_fullStr | HLA-DR Helps to Differentiate Erythrodermic Cutaneous T-cell Lymphoma from Erythrodermic Inflammatory Dermatoses in Flow Cytometry |
| title_full_unstemmed | HLA-DR Helps to Differentiate Erythrodermic Cutaneous T-cell Lymphoma from Erythrodermic Inflammatory Dermatoses in Flow Cytometry |
| title_short | HLA-DR Helps to Differentiate Erythrodermic Cutaneous T-cell Lymphoma from Erythrodermic Inflammatory Dermatoses in Flow Cytometry |
| title_sort | hla dr helps to differentiate erythrodermic cutaneous t cell lymphoma from erythrodermic inflammatory dermatoses in flow cytometry |
| topic | Erythroderma erythrodermic cutaneous T-cell lymphoma erythrodermic inflammatory dermatoses flow cytometry HLA-DR T helper 17 cells |
| url | https://medicaljournalssweden.se/actadv/article/view/5668 |
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