Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children
Developmental coordination disorder (DCD) is a developmental disorder characterized by impaired motor coordination, often co-occurring with attention deficit disorder, autism spectrum disorders, and other psychological and behavioural conditions. The aetiology of DCD is believed to involve brain cha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/6/940 |
| _version_ | 1797595718939049984 |
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| author | Haizhen You Junyao Shi Fangfang Huang Zhiyun Wei Gary Jones Wenchong Du Jing Hua |
| author_facet | Haizhen You Junyao Shi Fangfang Huang Zhiyun Wei Gary Jones Wenchong Du Jing Hua |
| author_sort | Haizhen You |
| collection | DOAJ |
| description | Developmental coordination disorder (DCD) is a developmental disorder characterized by impaired motor coordination, often co-occurring with attention deficit disorder, autism spectrum disorders, and other psychological and behavioural conditions. The aetiology of DCD is believed to involve brain changes and environmental factors, with genetics also playing a role in its pathogenesis. Recent research has identified several candidate genes and genetic factors associated with motor impairment, including deletions, copy number variations, single nucleotide polymorphisms, and epigenetic modifications. This review provides an overview of the current knowledge in genetic research on DCD, highlighting the importance of continued research into the underlying genetic mechanisms. While evidence suggests a genetic contribution to DCD, the evidence is still in its early stages, and much of the current evidence is based on studies of co-occurring conditions. Further research to better understand the genetic basis of DCD could have important implications for diagnosis, treatment, and our understanding of the condition’s aetiology. |
| first_indexed | 2024-03-11T02:41:23Z |
| format | Article |
| id | doaj.art-fe34ff90bd8840a0a18b59d19a0e6eaf |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T02:41:23Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-fe34ff90bd8840a0a18b59d19a0e6eaf2023-11-18T09:36:40ZengMDPI AGBrain Sciences2076-34252023-06-0113694010.3390/brainsci13060940Advances in Genetics and Epigenetics of Developmental Coordination Disorder in ChildrenHaizhen You0Junyao Shi1Fangfang Huang2Zhiyun Wei3Gary Jones4Wenchong Du5Jing Hua6Department of Women and Children’s Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200120, ChinaWomen and Children Health Care Institution of Pudong District, Shanghai 200021, ChinaDepartment of Women and Children’s Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200120, ChinaDepartment of Women and Children’s Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200120, ChinaNTU Psychology, School of Social Sciences, Nottingham Trent University, Nottingham NG1 6AA, UKNTU Psychology, School of Social Sciences, Nottingham Trent University, Nottingham NG1 6AA, UKDepartment of Women and Children’s Health Care, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 200120, ChinaDevelopmental coordination disorder (DCD) is a developmental disorder characterized by impaired motor coordination, often co-occurring with attention deficit disorder, autism spectrum disorders, and other psychological and behavioural conditions. The aetiology of DCD is believed to involve brain changes and environmental factors, with genetics also playing a role in its pathogenesis. Recent research has identified several candidate genes and genetic factors associated with motor impairment, including deletions, copy number variations, single nucleotide polymorphisms, and epigenetic modifications. This review provides an overview of the current knowledge in genetic research on DCD, highlighting the importance of continued research into the underlying genetic mechanisms. While evidence suggests a genetic contribution to DCD, the evidence is still in its early stages, and much of the current evidence is based on studies of co-occurring conditions. Further research to better understand the genetic basis of DCD could have important implications for diagnosis, treatment, and our understanding of the condition’s aetiology.https://www.mdpi.com/2076-3425/13/6/940developmental coordination disorder (DCD)geneticsco-occurrence |
| spellingShingle | Haizhen You Junyao Shi Fangfang Huang Zhiyun Wei Gary Jones Wenchong Du Jing Hua Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children Brain Sciences developmental coordination disorder (DCD) genetics co-occurrence |
| title | Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children |
| title_full | Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children |
| title_fullStr | Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children |
| title_full_unstemmed | Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children |
| title_short | Advances in Genetics and Epigenetics of Developmental Coordination Disorder in Children |
| title_sort | advances in genetics and epigenetics of developmental coordination disorder in children |
| topic | developmental coordination disorder (DCD) genetics co-occurrence |
| url | https://www.mdpi.com/2076-3425/13/6/940 |
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