Impact of Genetic Variability in ACE2 Expression on the Evolutionary Dynamics of SARS-CoV-2 Spike D614G Mutation

Impact of Genetic Variability in ACE2 Expression on the Evolutionary Dynamics of SARS-CoV-2 Spike D614G Mutation

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) glycoprotein D614G mutation became the predominant globally circulating variant after its emergence in the early coronavirus disease 2019 (COVID-19) pandemic. Studies showed that this mutation results in an open conformation...

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Bibliographic Details
Main Authors: Szu-Wei Huang, Sorin O. Miller, Chia-Hung Yen, Sheng-Fan Wang
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Genes
Subjects:
SARS-CoV-2
spike
D 614G
evolution
genetic variation
ACE2
Online Access:https://www.mdpi.com/2073-4425/12/1/16

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