Molecular Evolution of Peste des Petits Ruminants Virus
Despite safe and efficacious vaccines against peste des petits ruminants virus (PPRV), this virus has emerged as the cause of a highly contagious disease with serious economic consequences for small ruminant agriculture across Asia, the Middle East, and Africa. We used complete and partial genome se...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2014-12-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/20/12/14-0684_article |
| _version_ | 1818189933057146880 |
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| author | Murali Muniraju Muhammad Munir AravindhBabu R. Parthiban Ashley Banyard Jingyue Bao Zhiliang Wang Chrisostom Ayebazibwe Gelagay Ayelet Mehdi El Harrak Mana Mahapatra Geneviève Libeau Carrie Batten Satya Parida |
| author_facet | Murali Muniraju Muhammad Munir AravindhBabu R. Parthiban Ashley Banyard Jingyue Bao Zhiliang Wang Chrisostom Ayebazibwe Gelagay Ayelet Mehdi El Harrak Mana Mahapatra Geneviève Libeau Carrie Batten Satya Parida |
| author_sort | Murali Muniraju |
| collection | DOAJ |
| description | Despite safe and efficacious vaccines against peste des petits ruminants virus (PPRV), this virus has emerged as the cause of a highly contagious disease with serious economic consequences for small ruminant agriculture across Asia, the Middle East, and Africa. We used complete and partial genome sequences of all 4 lineages of the virus to investigate evolutionary and epidemiologic dynamics of PPRV. A Bayesian phylogenetic analysis of all PPRV lineages mapped the time to most recent common ancestor and initial divergence of PPRV to a lineage III isolate at the beginning of 20th century. A phylogeographic approach estimated the probability for root location of an ancestral PPRV and individual lineages as being Nigeria for PPRV, Senegal for lineage I, Nigeria/Ghana for lineage II, Sudan for lineage III, and India for lineage IV. Substitution rates are critical parameters for understanding virus evolution because restrictions in genetic variation can lead to lower adaptability and pathogenicity. |
| first_indexed | 2024-12-11T23:50:41Z |
| format | Article |
| id | doaj.art-fe3b28284fde48459dc403a480bdcbdd |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T23:50:41Z |
| publishDate | 2014-12-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-fe3b28284fde48459dc403a480bdcbdd2022-12-22T00:45:29ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592014-12-0120122023203310.3201/eid2012.140684Molecular Evolution of Peste des Petits Ruminants VirusMurali MunirajuMuhammad MunirAravindhBabu R. ParthibanAshley BanyardJingyue BaoZhiliang WangChrisostom AyebazibweGelagay AyeletMehdi El HarrakMana MahapatraGeneviève LibeauCarrie BattenSatya ParidaDespite safe and efficacious vaccines against peste des petits ruminants virus (PPRV), this virus has emerged as the cause of a highly contagious disease with serious economic consequences for small ruminant agriculture across Asia, the Middle East, and Africa. We used complete and partial genome sequences of all 4 lineages of the virus to investigate evolutionary and epidemiologic dynamics of PPRV. A Bayesian phylogenetic analysis of all PPRV lineages mapped the time to most recent common ancestor and initial divergence of PPRV to a lineage III isolate at the beginning of 20th century. A phylogeographic approach estimated the probability for root location of an ancestral PPRV and individual lineages as being Nigeria for PPRV, Senegal for lineage I, Nigeria/Ghana for lineage II, Sudan for lineage III, and India for lineage IV. Substitution rates are critical parameters for understanding virus evolution because restrictions in genetic variation can lead to lower adaptability and pathogenicity.https://wwwnc.cdc.gov/eid/article/20/12/14-0684_articlepeste des petits ruminants virusPPRVrinderpest virusmeasles virusvirusesemergence |
| spellingShingle | Murali Muniraju Muhammad Munir AravindhBabu R. Parthiban Ashley Banyard Jingyue Bao Zhiliang Wang Chrisostom Ayebazibwe Gelagay Ayelet Mehdi El Harrak Mana Mahapatra Geneviève Libeau Carrie Batten Satya Parida Molecular Evolution of Peste des Petits Ruminants Virus Emerging Infectious Diseases peste des petits ruminants virus PPRV rinderpest virus measles virus viruses emergence |
| title | Molecular Evolution of Peste des Petits Ruminants Virus |
| title_full | Molecular Evolution of Peste des Petits Ruminants Virus |
| title_fullStr | Molecular Evolution of Peste des Petits Ruminants Virus |
| title_full_unstemmed | Molecular Evolution of Peste des Petits Ruminants Virus |
| title_short | Molecular Evolution of Peste des Petits Ruminants Virus |
| title_sort | molecular evolution of peste des petits ruminants virus |
| topic | peste des petits ruminants virus PPRV rinderpest virus measles virus viruses emergence |
| url | https://wwwnc.cdc.gov/eid/article/20/12/14-0684_article |
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