Sunitinib induced resistance of endothelial cells by up-regulating P-glycoprotein and PI3K/Akt pathway

Sunitinib induced resistance of endothelial cells by up-regulating P-glycoprotein and PI3K/Akt pathway

Abstract Drug resistance is a crucial obstacle to achieve satisfactory chemotherapeutic effects. Numerous studies have shown that the PI3K/Akt signaling pathway plays a significant role in various processes of cellular events and tumor progression, while few studies have focused on the PI3K/Akt sign...

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Bibliographic Details
Main Authors:	Rong Zhang, Limin Huang, Di Pan, Wen Zhang
Format:	Article
Language:	English
Published:	Universidade de São Paulo 2022-09-01
Series:	Brazilian Journal of Pharmaceutical Sciences
Subjects:	Drug resistance Endothelial cells P-glycoprotein Sunitinib PI3K/Akt pathway
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100700&tlng=en

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