Molecular Basis of Encapsidation of Hepatitis C Virus Genome
Hepatitis C virus (HCV), a major etiologic agent of human liver diseases, is a positive-sense single-stranded RNA virus and is classified in the Flaviviridae family. Although research findings for the assembly of HCV particles are accumulating due to development of HCV cell culture system, the mecha...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-03-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fmicb.2018.00396/full |
| _version_ | 1818497498114686976 |
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| author | Guoli Shi Tetsuro Suzuki |
| author_facet | Guoli Shi Tetsuro Suzuki |
| author_sort | Guoli Shi |
| collection | DOAJ |
| description | Hepatitis C virus (HCV), a major etiologic agent of human liver diseases, is a positive-sense single-stranded RNA virus and is classified in the Flaviviridae family. Although research findings for the assembly of HCV particles are accumulating due to development of HCV cell culture system, the mechanism(s) by which the HCV genome becomes encapsidated remains largely unclear. In general, viral RNA represents only a small fraction of the RNA molecules in the cells infected with RNA viruses, but the viral genomic RNA is considered to selectively packaged into virions. It was recently demonstrated that HCV RNAs containing 3′ end of the genome are selectively incorporated into virus particles during the assembly process and the 3′ untranslated region functions as a cis-acting element for RNA packaging. Here, we discuss the molecular basis of RNA encapsidation of HCV and classical flaviviruses, contrast with the packaging mechanism of HIV-1. |
| first_indexed | 2024-12-10T18:46:29Z |
| format | Article |
| id | doaj.art-fe3c0ad7a0364a338df29a859cc6eb34 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-10T18:46:29Z |
| publishDate | 2018-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-fe3c0ad7a0364a338df29a859cc6eb342022-12-22T01:37:29ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2018-03-01910.3389/fmicb.2018.00396348873Molecular Basis of Encapsidation of Hepatitis C Virus GenomeGuoli Shi0Tetsuro Suzuki1Antiviral Immunity and Resistance Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, United StatesDepartment of Virology and Parasitology, Hamamatsu University School of Medicine, Hamamatsu, JapanHepatitis C virus (HCV), a major etiologic agent of human liver diseases, is a positive-sense single-stranded RNA virus and is classified in the Flaviviridae family. Although research findings for the assembly of HCV particles are accumulating due to development of HCV cell culture system, the mechanism(s) by which the HCV genome becomes encapsidated remains largely unclear. In general, viral RNA represents only a small fraction of the RNA molecules in the cells infected with RNA viruses, but the viral genomic RNA is considered to selectively packaged into virions. It was recently demonstrated that HCV RNAs containing 3′ end of the genome are selectively incorporated into virus particles during the assembly process and the 3′ untranslated region functions as a cis-acting element for RNA packaging. Here, we discuss the molecular basis of RNA encapsidation of HCV and classical flaviviruses, contrast with the packaging mechanism of HIV-1.http://journal.frontiersin.org/article/10.3389/fmicb.2018.00396/fullhepatitis C virusencapsidationpackaging signalcis-acting elementvirion assembly |
| spellingShingle | Guoli Shi Tetsuro Suzuki Molecular Basis of Encapsidation of Hepatitis C Virus Genome Frontiers in Microbiology hepatitis C virus encapsidation packaging signal cis-acting element virion assembly |
| title | Molecular Basis of Encapsidation of Hepatitis C Virus Genome |
| title_full | Molecular Basis of Encapsidation of Hepatitis C Virus Genome |
| title_fullStr | Molecular Basis of Encapsidation of Hepatitis C Virus Genome |
| title_full_unstemmed | Molecular Basis of Encapsidation of Hepatitis C Virus Genome |
| title_short | Molecular Basis of Encapsidation of Hepatitis C Virus Genome |
| title_sort | molecular basis of encapsidation of hepatitis c virus genome |
| topic | hepatitis C virus encapsidation packaging signal cis-acting element virion assembly |
| url | http://journal.frontiersin.org/article/10.3389/fmicb.2018.00396/full |
| work_keys_str_mv | AT guolishi molecularbasisofencapsidationofhepatitiscvirusgenome AT tetsurosuzuki molecularbasisofencapsidationofhepatitiscvirusgenome |