Pathogenesis and treatment of multiple myeloma bone disease
Multiple myeloma (Plasma cell myeloma), a malignancy of the plasma cells, exhibits tumor expansion preferentially in the bone marrow and the development of bone-destructive lesions. Multiple myeloma is still an incurable disease with changes in the bone marrow microenvironment in favor of the surviv...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Japanese Dental Science Review |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761621000235 |
| _version_ | 1819099214783709184 |
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| author | Masahiro Hiasa Takeshi Harada Eiji Tanaka Masahiro Abe |
| author_facet | Masahiro Hiasa Takeshi Harada Eiji Tanaka Masahiro Abe |
| author_sort | Masahiro Hiasa |
| collection | DOAJ |
| description | Multiple myeloma (Plasma cell myeloma), a malignancy of the plasma cells, exhibits tumor expansion preferentially in the bone marrow and the development of bone-destructive lesions. Multiple myeloma is still an incurable disease with changes in the bone marrow microenvironment in favor of the survival and proliferation of multiple myeloma cells and bone destruction. In this review, we described the recent findings on the regulators involved in the development of myeloma bone diseases, and succinctly summarize currently available therapeutic options and the development of novel bone modifying agents for myeloma treatment. |
| first_indexed | 2024-12-22T00:43:20Z |
| format | Article |
| id | doaj.art-fe3d076dc0ad42278f79e2769a0f992f |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-12-22T00:43:20Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-fe3d076dc0ad42278f79e2769a0f992f2022-12-21T18:44:38ZengElsevierJapanese Dental Science Review1882-76162021-11-0157164173Pathogenesis and treatment of multiple myeloma bone diseaseMasahiro Hiasa0Takeshi Harada1Eiji Tanaka2Masahiro Abe3Department of Orthodontics and Dentofacial Orthopedics, Tokushima University, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan; Corresponding author at: Department of Orthodontics and Dentofacial Orthopedics, Tokushima University Graduate School, 3-18-15 Kuramoto, Tokushima, 770-8504, Japan.Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, JapanDepartment of Orthodontics and Dentofacial Orthopedics, Tokushima University, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, JapanDepartment of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, JapanMultiple myeloma (Plasma cell myeloma), a malignancy of the plasma cells, exhibits tumor expansion preferentially in the bone marrow and the development of bone-destructive lesions. Multiple myeloma is still an incurable disease with changes in the bone marrow microenvironment in favor of the survival and proliferation of multiple myeloma cells and bone destruction. In this review, we described the recent findings on the regulators involved in the development of myeloma bone diseases, and succinctly summarize currently available therapeutic options and the development of novel bone modifying agents for myeloma treatment.http://www.sciencedirect.com/science/article/pii/S1882761621000235Multiple myeloma (Plasma cell myeloma)Bone diseasesOsteoclastsOsteoblastsOsteocytes |
| spellingShingle | Masahiro Hiasa Takeshi Harada Eiji Tanaka Masahiro Abe Pathogenesis and treatment of multiple myeloma bone disease Japanese Dental Science Review Multiple myeloma (Plasma cell myeloma) Bone diseases Osteoclasts Osteoblasts Osteocytes |
| title | Pathogenesis and treatment of multiple myeloma bone disease |
| title_full | Pathogenesis and treatment of multiple myeloma bone disease |
| title_fullStr | Pathogenesis and treatment of multiple myeloma bone disease |
| title_full_unstemmed | Pathogenesis and treatment of multiple myeloma bone disease |
| title_short | Pathogenesis and treatment of multiple myeloma bone disease |
| title_sort | pathogenesis and treatment of multiple myeloma bone disease |
| topic | Multiple myeloma (Plasma cell myeloma) Bone diseases Osteoclasts Osteoblasts Osteocytes |
| url | http://www.sciencedirect.com/science/article/pii/S1882761621000235 |
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