Transcriptomic Analysis Reveals the Inability of Recombinant AAV8 to Activate Human Monocyte-Derived Dendritic Cells

Transcriptomic Analysis Reveals the Inability of Recombinant AAV8 to Activate Human Monocyte-Derived Dendritic Cells

Recombinant Adeno-Associated Virus (rAAV) is considered as one of the most successful and widely used viral vectors for in vivo gene therapy. However, host immune responses to the vector and/or the transgene product remain a major hurdle to successful AAV gene transfer. In contrast to antivector ada...

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Bibliographic Details
Main Authors: Samer Masri, Laure Carré, Nicolas Jaulin, Céline Vandamme, Célia Couzinié, Aurélien Guy-Duché, Jean-Baptiste Dupont, Allwyn Pereira, Eric Charpentier, Laurent David, Gwladys Gernoux, Mickaël Guilbaud, Oumeya Adjali
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
cell–virus interaction
AAV
innate immunity
gene therapy
human-monocyte-derived dendritic cells
transcriptomic analysis
Online Access:https://www.mdpi.com/1422-0067/24/13/10447

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https://www.mdpi.com/1422-0067/24/13/10447

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