Progress in the Surface Functionalization of Selenium Nanoparticles and Their Potential Application in Cancer Therapy
As an essential micronutrient, selenium participates in numerous life processes and plays a key role in human health. In the past decade, selenium nanoparticles (SeNPs) have attracted great attention due to their excellent functionality for potential applications in pharmaceuticals. However, the uti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/10/1965 |
| _version_ | 1827652055473324032 |
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| author | Wanwen Chen Hao Cheng Wenshui Xia |
| author_facet | Wanwen Chen Hao Cheng Wenshui Xia |
| author_sort | Wanwen Chen |
| collection | DOAJ |
| description | As an essential micronutrient, selenium participates in numerous life processes and plays a key role in human health. In the past decade, selenium nanoparticles (SeNPs) have attracted great attention due to their excellent functionality for potential applications in pharmaceuticals. However, the utilization of SeNPs has been restricted by their instability and low targeting ability. Since the existing reviews mainly focused on the applications of SeNPs, this review highlights the synthesis of SeNPs and the strategies to improve their stability and targeting ability through surface functionalization. In addition, the utilization of functionalized SeNPs for the single and co-delivery of drugs or genes to achieve the combination of therapy are also presented, with the emphasis on the potential mechanism. The current challenges and prospects of functionalized SeNPs are also summarized. This review may provide valuable information for the design of novel functionalized SeNPs and promote their future application in cancer therapy. |
| first_indexed | 2024-03-09T20:49:09Z |
| format | Article |
| id | doaj.art-fe3eba9d76b641d693d6a32c423ad7a3 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T20:49:09Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-fe3eba9d76b641d693d6a32c423ad7a32023-11-23T22:38:35ZengMDPI AGAntioxidants2076-39212022-09-011110196510.3390/antiox11101965Progress in the Surface Functionalization of Selenium Nanoparticles and Their Potential Application in Cancer TherapyWanwen Chen0Hao Cheng1Wenshui Xia2State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaAs an essential micronutrient, selenium participates in numerous life processes and plays a key role in human health. In the past decade, selenium nanoparticles (SeNPs) have attracted great attention due to their excellent functionality for potential applications in pharmaceuticals. However, the utilization of SeNPs has been restricted by their instability and low targeting ability. Since the existing reviews mainly focused on the applications of SeNPs, this review highlights the synthesis of SeNPs and the strategies to improve their stability and targeting ability through surface functionalization. In addition, the utilization of functionalized SeNPs for the single and co-delivery of drugs or genes to achieve the combination of therapy are also presented, with the emphasis on the potential mechanism. The current challenges and prospects of functionalized SeNPs are also summarized. This review may provide valuable information for the design of novel functionalized SeNPs and promote their future application in cancer therapy.https://www.mdpi.com/2076-3921/11/10/1965selenium nanoparticlessurface functionalizationstabilitytargeting deliveryanticancer activity |
| spellingShingle | Wanwen Chen Hao Cheng Wenshui Xia Progress in the Surface Functionalization of Selenium Nanoparticles and Their Potential Application in Cancer Therapy Antioxidants selenium nanoparticles surface functionalization stability targeting delivery anticancer activity |
| title | Progress in the Surface Functionalization of Selenium Nanoparticles and Their Potential Application in Cancer Therapy |
| title_full | Progress in the Surface Functionalization of Selenium Nanoparticles and Their Potential Application in Cancer Therapy |
| title_fullStr | Progress in the Surface Functionalization of Selenium Nanoparticles and Their Potential Application in Cancer Therapy |
| title_full_unstemmed | Progress in the Surface Functionalization of Selenium Nanoparticles and Their Potential Application in Cancer Therapy |
| title_short | Progress in the Surface Functionalization of Selenium Nanoparticles and Their Potential Application in Cancer Therapy |
| title_sort | progress in the surface functionalization of selenium nanoparticles and their potential application in cancer therapy |
| topic | selenium nanoparticles surface functionalization stability targeting delivery anticancer activity |
| url | https://www.mdpi.com/2076-3921/11/10/1965 |
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