A treatment within sight: challenges in the development of stem cell-derived photoreceptor therapies for retinal degenerative diseases
Stem cell therapies can potentially treat various retinal degenerative diseases, including age-related macular degeneration (AMD) and inherited retinal diseases like retinitis pigmentosa. For these diseases, transplanted cells may include stem cell-derived retinal pigmented epithelial (RPE) cells, p...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-09-01
|
| Series: | Frontiers in Transplantation |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/frtra.2023.1130086/full |
| _version_ | 1797670895114780672 |
|---|---|
| author | Davinia Beaver Ioannis Jason Limnios |
| author_facet | Davinia Beaver Ioannis Jason Limnios |
| author_sort | Davinia Beaver |
| collection | DOAJ |
| description | Stem cell therapies can potentially treat various retinal degenerative diseases, including age-related macular degeneration (AMD) and inherited retinal diseases like retinitis pigmentosa. For these diseases, transplanted cells may include stem cell-derived retinal pigmented epithelial (RPE) cells, photoreceptors, or a combination of both. Although stem cell-derived RPE cells have progressed to human clinical trials, therapies using photoreceptors and other retinal cell types are lagging. In this review, we discuss the potential use of human pluripotent stem cell (hPSC)-derived photoreceptors for the treatment of retinal degeneration and highlight the progress and challenges for their efficient production and clinical application in regenerative medicine. |
| first_indexed | 2024-03-11T21:07:26Z |
| format | Article |
| id | doaj.art-fe3f247999234015894b688ac8fb8324 |
| institution | Directory Open Access Journal |
| issn | 2813-2440 |
| language | English |
| last_indexed | 2024-03-11T21:07:26Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Transplantation |
| spelling | doaj.art-fe3f247999234015894b688ac8fb83242023-09-29T12:36:17ZengFrontiers Media S.A.Frontiers in Transplantation2813-24402023-09-01210.3389/frtra.2023.11300861130086A treatment within sight: challenges in the development of stem cell-derived photoreceptor therapies for retinal degenerative diseasesDavinia BeaverIoannis Jason LimniosStem cell therapies can potentially treat various retinal degenerative diseases, including age-related macular degeneration (AMD) and inherited retinal diseases like retinitis pigmentosa. For these diseases, transplanted cells may include stem cell-derived retinal pigmented epithelial (RPE) cells, photoreceptors, or a combination of both. Although stem cell-derived RPE cells have progressed to human clinical trials, therapies using photoreceptors and other retinal cell types are lagging. In this review, we discuss the potential use of human pluripotent stem cell (hPSC)-derived photoreceptors for the treatment of retinal degeneration and highlight the progress and challenges for their efficient production and clinical application in regenerative medicine.https://www.frontiersin.org/articles/10.3389/frtra.2023.1130086/fullretinal degenerationregenerative medicinehuman pluripotent stem cellsphotoreceptorscell therapyretinal organoids |
| spellingShingle | Davinia Beaver Ioannis Jason Limnios A treatment within sight: challenges in the development of stem cell-derived photoreceptor therapies for retinal degenerative diseases Frontiers in Transplantation retinal degeneration regenerative medicine human pluripotent stem cells photoreceptors cell therapy retinal organoids |
| title | A treatment within sight: challenges in the development of stem cell-derived photoreceptor therapies for retinal degenerative diseases |
| title_full | A treatment within sight: challenges in the development of stem cell-derived photoreceptor therapies for retinal degenerative diseases |
| title_fullStr | A treatment within sight: challenges in the development of stem cell-derived photoreceptor therapies for retinal degenerative diseases |
| title_full_unstemmed | A treatment within sight: challenges in the development of stem cell-derived photoreceptor therapies for retinal degenerative diseases |
| title_short | A treatment within sight: challenges in the development of stem cell-derived photoreceptor therapies for retinal degenerative diseases |
| title_sort | treatment within sight challenges in the development of stem cell derived photoreceptor therapies for retinal degenerative diseases |
| topic | retinal degeneration regenerative medicine human pluripotent stem cells photoreceptors cell therapy retinal organoids |
| url | https://www.frontiersin.org/articles/10.3389/frtra.2023.1130086/full |
| work_keys_str_mv | AT daviniabeaver atreatmentwithinsightchallengesinthedevelopmentofstemcellderivedphotoreceptortherapiesforretinaldegenerativediseases AT ioannisjasonlimnios atreatmentwithinsightchallengesinthedevelopmentofstemcellderivedphotoreceptortherapiesforretinaldegenerativediseases AT daviniabeaver treatmentwithinsightchallengesinthedevelopmentofstemcellderivedphotoreceptortherapiesforretinaldegenerativediseases AT ioannisjasonlimnios treatmentwithinsightchallengesinthedevelopmentofstemcellderivedphotoreceptortherapiesforretinaldegenerativediseases |