Plasma asymmetric dimethylarginine is associated with vulnerable plaque and long-term outcomes in stable coronary artery disease
Abstract Asymmetric dimethylarginine (ADMA) is considered to be an atherogenic molecule. We aimed to investigate the relationship between ADMA and plaque vulnerability assessed by optical coherence tomography (OCT) in patients with stable coronary artery disease (CAD). Two hundred and forty-five pat...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-05-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-32728-9 |
| _version_ | 1797827616208584704 |
|---|---|
| author | Shao-Sung Huang Wei-Chieh Huang Chuan-Tsai Tsai Ying-Ying Chen Sheng-Hua Lee Tse-Min Lu |
| author_facet | Shao-Sung Huang Wei-Chieh Huang Chuan-Tsai Tsai Ying-Ying Chen Sheng-Hua Lee Tse-Min Lu |
| author_sort | Shao-Sung Huang |
| collection | DOAJ |
| description | Abstract Asymmetric dimethylarginine (ADMA) is considered to be an atherogenic molecule. We aimed to investigate the relationship between ADMA and plaque vulnerability assessed by optical coherence tomography (OCT) in patients with stable coronary artery disease (CAD). Two hundred and forty-five patients with stable CAD undergoing OCT-guided percutaneous coronary intervention were included in this study and were divided into two groups according to their ADMA levels. Micro-vessel, macrophage accumulation, thin-cap fibroatheroma, intra-plaque calcium and lipid core content, and vulnerable score (VS) were evaluated by OCT analysis. The patients with higher ADMA levels had significantly higher calcium and lipid content (p < 0.001, respectively). There were significantly more micro-vessel and macrophage (32.8%, p = 0.004 and 52.5%, p < 0.001, respectively) and higher VS (87.7 ± 17.6, p < 0.001) in the higher ADMA group. Moreover, plasma ADMA level was significantly correlated with the intra-plaque lipid, calcium content and VS (p < 0.001, respectively). Plasma ADMA level was identified as an independent predictor of future adverse cardiovascular events, following OCT-guided PCI. In patients with stable CAD, higher plasma ADMA levels were significantly associated with the presence of intra-plaque lipid, calcification, vulnerable plaque, and poor long-term outcomes. |
| first_indexed | 2024-04-09T12:51:11Z |
| format | Article |
| id | doaj.art-fe3f4ba01b694c4086aff232ab12f2c3 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T12:51:11Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-fe3f4ba01b694c4086aff232ab12f2c32023-05-14T11:15:43ZengNature PortfolioScientific Reports2045-23222023-05-0113111010.1038/s41598-023-32728-9Plasma asymmetric dimethylarginine is associated with vulnerable plaque and long-term outcomes in stable coronary artery diseaseShao-Sung Huang0Wei-Chieh Huang1Chuan-Tsai Tsai2Ying-Ying Chen3Sheng-Hua Lee4Tse-Min Lu5Division of Cardiology, Department of Internal Medicine, Taipei Veterans General HospitalDivision of Cardiology, Department of Internal Medicine, Taipei Veterans General HospitalDivision of Cardiology, Department of Internal Medicine, Taipei Veterans General HospitalDivision of Nephrology, Department of Internal Medicine, MacKay Memorial HospitalDivision of Cardiology, Department of Internal Medicine, Taipei Veterans General HospitalDivision of Cardiology, Department of Internal Medicine, Taipei Veterans General HospitalAbstract Asymmetric dimethylarginine (ADMA) is considered to be an atherogenic molecule. We aimed to investigate the relationship between ADMA and plaque vulnerability assessed by optical coherence tomography (OCT) in patients with stable coronary artery disease (CAD). Two hundred and forty-five patients with stable CAD undergoing OCT-guided percutaneous coronary intervention were included in this study and were divided into two groups according to their ADMA levels. Micro-vessel, macrophage accumulation, thin-cap fibroatheroma, intra-plaque calcium and lipid core content, and vulnerable score (VS) were evaluated by OCT analysis. The patients with higher ADMA levels had significantly higher calcium and lipid content (p < 0.001, respectively). There were significantly more micro-vessel and macrophage (32.8%, p = 0.004 and 52.5%, p < 0.001, respectively) and higher VS (87.7 ± 17.6, p < 0.001) in the higher ADMA group. Moreover, plasma ADMA level was significantly correlated with the intra-plaque lipid, calcium content and VS (p < 0.001, respectively). Plasma ADMA level was identified as an independent predictor of future adverse cardiovascular events, following OCT-guided PCI. In patients with stable CAD, higher plasma ADMA levels were significantly associated with the presence of intra-plaque lipid, calcification, vulnerable plaque, and poor long-term outcomes.https://doi.org/10.1038/s41598-023-32728-9 |
| spellingShingle | Shao-Sung Huang Wei-Chieh Huang Chuan-Tsai Tsai Ying-Ying Chen Sheng-Hua Lee Tse-Min Lu Plasma asymmetric dimethylarginine is associated with vulnerable plaque and long-term outcomes in stable coronary artery disease Scientific Reports |
| title | Plasma asymmetric dimethylarginine is associated with vulnerable plaque and long-term outcomes in stable coronary artery disease |
| title_full | Plasma asymmetric dimethylarginine is associated with vulnerable plaque and long-term outcomes in stable coronary artery disease |
| title_fullStr | Plasma asymmetric dimethylarginine is associated with vulnerable plaque and long-term outcomes in stable coronary artery disease |
| title_full_unstemmed | Plasma asymmetric dimethylarginine is associated with vulnerable plaque and long-term outcomes in stable coronary artery disease |
| title_short | Plasma asymmetric dimethylarginine is associated with vulnerable plaque and long-term outcomes in stable coronary artery disease |
| title_sort | plasma asymmetric dimethylarginine is associated with vulnerable plaque and long term outcomes in stable coronary artery disease |
| url | https://doi.org/10.1038/s41598-023-32728-9 |
| work_keys_str_mv | AT shaosunghuang plasmaasymmetricdimethylarginineisassociatedwithvulnerableplaqueandlongtermoutcomesinstablecoronaryarterydisease AT weichiehhuang plasmaasymmetricdimethylarginineisassociatedwithvulnerableplaqueandlongtermoutcomesinstablecoronaryarterydisease AT chuantsaitsai plasmaasymmetricdimethylarginineisassociatedwithvulnerableplaqueandlongtermoutcomesinstablecoronaryarterydisease AT yingyingchen plasmaasymmetricdimethylarginineisassociatedwithvulnerableplaqueandlongtermoutcomesinstablecoronaryarterydisease AT shenghualee plasmaasymmetricdimethylarginineisassociatedwithvulnerableplaqueandlongtermoutcomesinstablecoronaryarterydisease AT tseminlu plasmaasymmetricdimethylarginineisassociatedwithvulnerableplaqueandlongtermoutcomesinstablecoronaryarterydisease |