NGF Eye Administration Recovers the TrkB and Glutamate/GABA Marker Deficit in the Adult Visual Cortex Following Optic Nerve Crush

NGF Eye Administration Recovers the TrkB and Glutamate/GABA Marker Deficit in the Adult Visual Cortex Following Optic Nerve Crush

Eye-drop recombinant human nerve growth factor (ed-rhNGF) has proved to recover the retina and optic nerve damage in animal models, including the unilateral optic nerve crush (ONC), and to improve visual acuity in humans. These data, associated with evidence that ed-rhNGF stimulates the brain derive...

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Bibliographic Details
Main Authors: Pamela Rosso, Elena Fico, Louise A. Mesentier-Louro, Viviana Triaca, Alessandro Lambiase, Paolo Rama, Paola Tirassa
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
BDNF
neurotrophins
optic nerve crush (ONC)
synaptic transmission
rat visual cortex (VCx)
GABA
Online Access:https://www.mdpi.com/1422-0067/22/18/10014

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