Investigating hypotheses of neurodegeneration by learning dynamical systems of protein propagation in the brain
We introduce a theoretical framework for estimating, comparing and interpreting mechanistic hypotheses on long term protein propagation across brain networks in neurodegenerative disorders (ND). The model is expressed within a Bayesian non-parametric regression setting, where mechanisms of protein d...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811921002573 |
| _version_ | 1829514205151100928 |
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| author | Sara Garbarino Marco Lorenzi |
| author_facet | Sara Garbarino Marco Lorenzi |
| author_sort | Sara Garbarino |
| collection | DOAJ |
| description | We introduce a theoretical framework for estimating, comparing and interpreting mechanistic hypotheses on long term protein propagation across brain networks in neurodegenerative disorders (ND). The model is expressed within a Bayesian non-parametric regression setting, where mechanisms of protein dynamics are inferred by means of gradient matching on dynamical systems (DS). The Bayesian formalism, combined with stochastic variational inference, naturally allows for model comparison via assessment of model evidence, while providing uncertainty quantification of causal relationship underlying protein progressions. When applied to in–vivo AV45-PET brain imaging data measuring topographic amyloid deposition in Alzheimer’s disease (AD), our model identified the mechanisms of accumulation, clearance and propagation as the best suited DS for bio-mechanical description of amyloid dynamics in AD, enabling realistic and accurate personalized simulation of amyloidosis. |
| first_indexed | 2024-12-16T13:13:36Z |
| format | Article |
| id | doaj.art-fe41610070134bfba40554d5500a5d6f |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-16T13:13:36Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-fe41610070134bfba40554d5500a5d6f2022-12-21T22:30:32ZengElsevierNeuroImage1095-95722021-07-01235117980Investigating hypotheses of neurodegeneration by learning dynamical systems of protein propagation in the brainSara Garbarino0Marco Lorenzi1Corresponding author.; Universitè Côte d’Azur, Inria, Epione Research Project, FranceUniversitè Côte d’Azur, Inria, Epione Research Project, FranceWe introduce a theoretical framework for estimating, comparing and interpreting mechanistic hypotheses on long term protein propagation across brain networks in neurodegenerative disorders (ND). The model is expressed within a Bayesian non-parametric regression setting, where mechanisms of protein dynamics are inferred by means of gradient matching on dynamical systems (DS). The Bayesian formalism, combined with stochastic variational inference, naturally allows for model comparison via assessment of model evidence, while providing uncertainty quantification of causal relationship underlying protein progressions. When applied to in–vivo AV45-PET brain imaging data measuring topographic amyloid deposition in Alzheimer’s disease (AD), our model identified the mechanisms of accumulation, clearance and propagation as the best suited DS for bio-mechanical description of amyloid dynamics in AD, enabling realistic and accurate personalized simulation of amyloidosis.http://www.sciencedirect.com/science/article/pii/S1053811921002573NeurodegenerationCausal modelDynamical systemsProtein propagationGaussian processBrain connectivity |
| spellingShingle | Sara Garbarino Marco Lorenzi Investigating hypotheses of neurodegeneration by learning dynamical systems of protein propagation in the brain NeuroImage Neurodegeneration Causal model Dynamical systems Protein propagation Gaussian process Brain connectivity |
| title | Investigating hypotheses of neurodegeneration by learning dynamical systems of protein propagation in the brain |
| title_full | Investigating hypotheses of neurodegeneration by learning dynamical systems of protein propagation in the brain |
| title_fullStr | Investigating hypotheses of neurodegeneration by learning dynamical systems of protein propagation in the brain |
| title_full_unstemmed | Investigating hypotheses of neurodegeneration by learning dynamical systems of protein propagation in the brain |
| title_short | Investigating hypotheses of neurodegeneration by learning dynamical systems of protein propagation in the brain |
| title_sort | investigating hypotheses of neurodegeneration by learning dynamical systems of protein propagation in the brain |
| topic | Neurodegeneration Causal model Dynamical systems Protein propagation Gaussian process Brain connectivity |
| url | http://www.sciencedirect.com/science/article/pii/S1053811921002573 |
| work_keys_str_mv | AT saragarbarino investigatinghypothesesofneurodegenerationbylearningdynamicalsystemsofproteinpropagationinthebrain AT marcolorenzi investigatinghypothesesofneurodegenerationbylearningdynamicalsystemsofproteinpropagationinthebrain |