HPV-Related Neovaginal Squamous Cell Carcinoma Presenting as Lung Metastasis after Male-to-Female Gender Confirmation Surgery

There have been 4 reported cases of squamous cell carcinoma (SCC) of the neovagina in transgender women. In this report, we present another case of neovaginal SCC in a transgender woman, which was HPV-related, with lung metastasis as the initial presentation, and which was also complicated by her pr...

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Main Authors: Gang Wang, David Ferguson, Diana N. Ionescu, Lien Hoang, Sarah Barrett, Dirk van Niekerk, James Neil Rose, Christian Kollmannsberger
Format: Article
Language:English
Published: Karger Publishers 2020-01-01
Series:Case Reports in Oncology
Subjects:
Online Access:https://www.karger.com/Article/FullText/504936
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author Gang Wang
David Ferguson
Diana N. Ionescu
Lien Hoang
Sarah Barrett
Dirk van Niekerk
James Neil Rose
Christian Kollmannsberger
author_facet Gang Wang
David Ferguson
Diana N. Ionescu
Lien Hoang
Sarah Barrett
Dirk van Niekerk
James Neil Rose
Christian Kollmannsberger
author_sort Gang Wang
collection DOAJ
description There have been 4 reported cases of squamous cell carcinoma (SCC) of the neovagina in transgender women. In this report, we present another case of neovaginal SCC in a transgender woman, which was HPV-related, with lung metastasis as the initial presentation, and which was also complicated by her previous history of metastatic renal cell carcinoma. This unique case highlights the diagnostic challenges in these unusual scenarios. Through this report, we hope to address the benefits of multidisciplinary tumor board rounds, provision of detailed clinical information, and familiarization of the transgender anatomy within the pelvis in this group of patients. We also propose that transgender women undergo a continuous annual follow-up after postoperative follow-up is completed.
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spelling doaj.art-fe4185b038de493ba8f62c3ed8913f0e2022-12-22T02:05:51ZengKarger PublishersCase Reports in Oncology1662-65752020-01-01131172210.1159/000504936504936HPV-Related Neovaginal Squamous Cell Carcinoma Presenting as Lung Metastasis after Male-to-Female Gender Confirmation SurgeryGang WangDavid FergusonDiana N. IonescuLien HoangSarah BarrettDirk van NiekerkJames Neil RoseChristian KollmannsbergerThere have been 4 reported cases of squamous cell carcinoma (SCC) of the neovagina in transgender women. In this report, we present another case of neovaginal SCC in a transgender woman, which was HPV-related, with lung metastasis as the initial presentation, and which was also complicated by her previous history of metastatic renal cell carcinoma. This unique case highlights the diagnostic challenges in these unusual scenarios. Through this report, we hope to address the benefits of multidisciplinary tumor board rounds, provision of detailed clinical information, and familiarization of the transgender anatomy within the pelvis in this group of patients. We also propose that transgender women undergo a continuous annual follow-up after postoperative follow-up is completed.https://www.karger.com/Article/FullText/504936metastasistransgenderneovaginasquamous cell carcinomahpv
spellingShingle Gang Wang
David Ferguson
Diana N. Ionescu
Lien Hoang
Sarah Barrett
Dirk van Niekerk
James Neil Rose
Christian Kollmannsberger
HPV-Related Neovaginal Squamous Cell Carcinoma Presenting as Lung Metastasis after Male-to-Female Gender Confirmation Surgery
Case Reports in Oncology
metastasis
transgender
neovagina
squamous cell carcinoma
hpv
title HPV-Related Neovaginal Squamous Cell Carcinoma Presenting as Lung Metastasis after Male-to-Female Gender Confirmation Surgery
title_full HPV-Related Neovaginal Squamous Cell Carcinoma Presenting as Lung Metastasis after Male-to-Female Gender Confirmation Surgery
title_fullStr HPV-Related Neovaginal Squamous Cell Carcinoma Presenting as Lung Metastasis after Male-to-Female Gender Confirmation Surgery
title_full_unstemmed HPV-Related Neovaginal Squamous Cell Carcinoma Presenting as Lung Metastasis after Male-to-Female Gender Confirmation Surgery
title_short HPV-Related Neovaginal Squamous Cell Carcinoma Presenting as Lung Metastasis after Male-to-Female Gender Confirmation Surgery
title_sort hpv related neovaginal squamous cell carcinoma presenting as lung metastasis after male to female gender confirmation surgery
topic metastasis
transgender
neovagina
squamous cell carcinoma
hpv
url https://www.karger.com/Article/FullText/504936
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