Circulating Tumor Cells as a Promising Tool for Early Detection of Hepatocellular Carcinoma
Liver cancer is a significant contributor to the cancer burden, and its incidence rates have recently increased in almost all countries. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is the second leading cause of cancer-related deaths worldwide. Because of the l...
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| Format: | Article |
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MDPI AG
2023-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/18/2260 |
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| author | Mahsa Salehi Zohre Miri Lavasani Hani Keshavarz Alikhani Bahare Shokouhian Moustapha Hassan Mustapha Najimi Massoud Vosough |
| author_facet | Mahsa Salehi Zohre Miri Lavasani Hani Keshavarz Alikhani Bahare Shokouhian Moustapha Hassan Mustapha Najimi Massoud Vosough |
| author_sort | Mahsa Salehi |
| collection | DOAJ |
| description | Liver cancer is a significant contributor to the cancer burden, and its incidence rates have recently increased in almost all countries. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is the second leading cause of cancer-related deaths worldwide. Because of the late diagnosis and lack of efficient therapeutic modality for advanced stages of HCC, the death rate continues to increase by ~2–3% per year. Circulating tumor cells (CTCs) are promising tools for early diagnosis, precise prognosis, and follow-up of therapeutic responses. They can be considered to be an innovative biomarker for the early detection of tumors and targeted molecular therapy. In this review, we briefly discuss the novel materials and technologies applied for the practical isolation and detection of CTCs in HCC. Also, the clinical value of CTC detection in HCC is highlighted. |
| first_indexed | 2024-03-10T22:56:49Z |
| format | Article |
| id | doaj.art-fe41cc4d1b29457697abc28a64d17093 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T22:56:49Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-fe41cc4d1b29457697abc28a64d170932023-11-19T09:59:33ZengMDPI AGCells2073-44092023-09-011218226010.3390/cells12182260Circulating Tumor Cells as a Promising Tool for Early Detection of Hepatocellular CarcinomaMahsa Salehi0Zohre Miri Lavasani1Hani Keshavarz Alikhani2Bahare Shokouhian3Moustapha Hassan4Mustapha Najimi5Massoud Vosough6Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research, Tehran 1665666311, IranGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 1983969411, IranDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research, Tehran 1665666311, IranDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research, Tehran 1665666311, IranExperimental Cancer Medicine, Institution for Laboratory Medicine, Karolinska Institute, 171 77 Stockholm, SwedenLaboratory of Pediatric Hepatology and Cell Therapy, Institute of Experimental and Clinical Research (IREC), UCLouvain, B-1200 Brussels, BelgiumDepartment of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, Academic Center for Education, Culture and Research, Tehran 1665666311, IranLiver cancer is a significant contributor to the cancer burden, and its incidence rates have recently increased in almost all countries. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is the second leading cause of cancer-related deaths worldwide. Because of the late diagnosis and lack of efficient therapeutic modality for advanced stages of HCC, the death rate continues to increase by ~2–3% per year. Circulating tumor cells (CTCs) are promising tools for early diagnosis, precise prognosis, and follow-up of therapeutic responses. They can be considered to be an innovative biomarker for the early detection of tumors and targeted molecular therapy. In this review, we briefly discuss the novel materials and technologies applied for the practical isolation and detection of CTCs in HCC. Also, the clinical value of CTC detection in HCC is highlighted.https://www.mdpi.com/2073-4409/12/18/2260circulating tumor cellshepatocellular carcinomaearly diagnosisHCC biomarker |
| spellingShingle | Mahsa Salehi Zohre Miri Lavasani Hani Keshavarz Alikhani Bahare Shokouhian Moustapha Hassan Mustapha Najimi Massoud Vosough Circulating Tumor Cells as a Promising Tool for Early Detection of Hepatocellular Carcinoma Cells circulating tumor cells hepatocellular carcinoma early diagnosis HCC biomarker |
| title | Circulating Tumor Cells as a Promising Tool for Early Detection of Hepatocellular Carcinoma |
| title_full | Circulating Tumor Cells as a Promising Tool for Early Detection of Hepatocellular Carcinoma |
| title_fullStr | Circulating Tumor Cells as a Promising Tool for Early Detection of Hepatocellular Carcinoma |
| title_full_unstemmed | Circulating Tumor Cells as a Promising Tool for Early Detection of Hepatocellular Carcinoma |
| title_short | Circulating Tumor Cells as a Promising Tool for Early Detection of Hepatocellular Carcinoma |
| title_sort | circulating tumor cells as a promising tool for early detection of hepatocellular carcinoma |
| topic | circulating tumor cells hepatocellular carcinoma early diagnosis HCC biomarker |
| url | https://www.mdpi.com/2073-4409/12/18/2260 |
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