Stabilizers used in nano-crystal based drug delivery systems
Nanocrystals have emerged as a viable tool to increase oral bioavailability of poorly water soluble oral solid dosage drugs. They also enable parenteral administration of these drugs as nanosuspensions. The high free surface energy, due to the large surface area to volume ratio of nanocrystals, make...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
International Pharmaceutical Excipients Council
2016-10-01
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| Series: | Journal of Excipients and Food Chemicals |
| Online Access: | https://jefc.scholasticahq.com/article/941-stabilizers-used-in-nano-crystal-based-drug-delivery-systems |
| _version_ | 1797254414492237824 |
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| author | Ganesh Shete Hemant Jain Deeksha Punj Hitesh Prajapat Priya Akotiya Arvind Kumar Bansal |
| author_facet | Ganesh Shete Hemant Jain Deeksha Punj Hitesh Prajapat Priya Akotiya Arvind Kumar Bansal |
| author_sort | Ganesh Shete |
| collection | DOAJ |
| description | Nanocrystals have emerged as a viable tool to increase oral bioavailability of poorly water soluble oral solid dosage drugs. They also enable parenteral administration of these drugs as nanosuspensions. The high free surface energy, due to the large surface area to volume ratio of nanocrystals, makes them prone to aggregation, that can result in physical instability and loss of the previously increased solubility/dissolution. Stabilizers are incorporated into nanocrystalline formulations to prevent aggregation. These include excipients such as polymers and surfactants. They achieve stabilization though electrostatic repulsion and/or steric hindrance. This article focuses on aggregation in nanocrystal based formulations, stabilizers for the inhibition
of aggregation, classification of stabilizers, properties of stabilizers and the mechanisms involved in stabilization. A review of stabilizers, drugs that have been stabilized, formulation types and methods for generating nanocrystals will be presented. Current challenges and future trends in the field of stabilizers will also be reviewed. |
| first_indexed | 2024-04-24T21:49:35Z |
| format | Article |
| id | doaj.art-fe4397be56e545fbb792c84ea7da773e |
| institution | Directory Open Access Journal |
| issn | 2150-2668 |
| language | English |
| last_indexed | 2024-04-24T21:49:35Z |
| publishDate | 2016-10-01 |
| publisher | International Pharmaceutical Excipients Council |
| record_format | Article |
| series | Journal of Excipients and Food Chemicals |
| spelling | doaj.art-fe4397be56e545fbb792c84ea7da773e2024-03-20T18:01:28ZengInternational Pharmaceutical Excipients CouncilJournal of Excipients and Food Chemicals2150-26682016-10-0154Stabilizers used in nano-crystal based drug delivery systemsGanesh SheteHemant JainDeeksha PunjHitesh PrajapatPriya AkotiyaArvind Kumar BansalNanocrystals have emerged as a viable tool to increase oral bioavailability of poorly water soluble oral solid dosage drugs. They also enable parenteral administration of these drugs as nanosuspensions. The high free surface energy, due to the large surface area to volume ratio of nanocrystals, makes them prone to aggregation, that can result in physical instability and loss of the previously increased solubility/dissolution. Stabilizers are incorporated into nanocrystalline formulations to prevent aggregation. These include excipients such as polymers and surfactants. They achieve stabilization though electrostatic repulsion and/or steric hindrance. This article focuses on aggregation in nanocrystal based formulations, stabilizers for the inhibition of aggregation, classification of stabilizers, properties of stabilizers and the mechanisms involved in stabilization. A review of stabilizers, drugs that have been stabilized, formulation types and methods for generating nanocrystals will be presented. Current challenges and future trends in the field of stabilizers will also be reviewed.https://jefc.scholasticahq.com/article/941-stabilizers-used-in-nano-crystal-based-drug-delivery-systems |
| spellingShingle | Ganesh Shete Hemant Jain Deeksha Punj Hitesh Prajapat Priya Akotiya Arvind Kumar Bansal Stabilizers used in nano-crystal based drug delivery systems Journal of Excipients and Food Chemicals |
| title | Stabilizers used in nano-crystal based drug delivery systems |
| title_full | Stabilizers used in nano-crystal based drug delivery systems |
| title_fullStr | Stabilizers used in nano-crystal based drug delivery systems |
| title_full_unstemmed | Stabilizers used in nano-crystal based drug delivery systems |
| title_short | Stabilizers used in nano-crystal based drug delivery systems |
| title_sort | stabilizers used in nano crystal based drug delivery systems |
| url | https://jefc.scholasticahq.com/article/941-stabilizers-used-in-nano-crystal-based-drug-delivery-systems |
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