Application of a Human Blood Brain Barrier Organ-on-a-Chip Model to Evaluate Small Molecule Effectiveness against Venezuelan Equine Encephalitis Virus

Application of a Human Blood Brain Barrier Organ-on-a-Chip Model to Evaluate Small Molecule Effectiveness against Venezuelan Equine Encephalitis Virus

The blood brain barrier (BBB) is a multicellular microenvironment that plays an important role in regulating bidirectional transport to and from the central nervous system (CNS). Infections by many acutely infectious viruses such as alphaviruses and flaviviruses are known to impact the integrity of...

Full description

Bibliographic Details
Main Authors:	Niloufar A. Boghdeh, Kenneth H. Risner, Michael D. Barrera, Clayton M. Britt, David K. Schaffer, Farhang Alem, Jacquelyn A. Brown, John P. Wikswo, Aarthi Narayanan
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Series:	Viruses
Subjects:	Venezuelan Equine Encephalitis Virus alphaviruses neurovascular unit (NVU) organ-on-a-chip blood brain barrier omaveloxolone
Online Access:	https://www.mdpi.com/1999-4915/14/12/2799

Similar Items

Inhibitors of the Ubiquitin-Mediated Signaling Pathway Exhibit Broad-Spectrum Antiviral Activities against New World Alphaviruses
by: Niloufar A. Boghdeh, et al.
Published: (2023-02-01)

Venezuelan Equine Encephalitis Virus, Southern Mexico
by: José G. Estrada-Franco, et al.
Published: (2004-12-01)

Detection of Venezuelan Equine Encephalitis Virus from Brain Samples of Equines with Encephalitis
by: Bernal León, et al.
Published: (2023-08-01)

Equine Amplification and Virulence of Subtype IE Venezuelan Equine Encephalitis Viruses Isolated during the 1993 and 1996 Mexican Epizootics
by: Dante Gonzalez, et al.
Published: (2003-02-01)

Venezuelan Equine Encephalitis Virus Transmission and Effect on Pathogenesis
by: Darci R. Smith, et al.
Published: (2006-08-01)

Natural Enzootic Vectors of Venezuelan equine encephalitis virus in the Magdalena Valley, Colombia
by: Cristina Ferro, et al.
Published: (2003-01-01)

Endemic Venezuelan Equine Encephalitis in Northern Peru
by: Patricia V. Aguilar, et al.
Published: (2004-05-01)

Venezuelan Equine Encephalitis Virus Capsid Implicated in Infection-Induced Cell Cycle Delay in vitro
by: Lindsay Lundberg, et al.
Published: (2018-12-01)

Inhibition of Venezuelan Equine Encephalitis Virus Using Small Interfering RNAs
by: Amrita Haikerwal, et al.
Published: (2022-07-01)

Vaccine Advances against Venezuelan, Eastern, and Western Equine Encephalitis Viruses
by: Zachary R. Stromberg, et al.
Published: (2020-06-01)

Magnetic Nanotrap Particles Preserve the Stability of Venezuelan Equine Encephalitis Virus in Blood for Laboratory Detection
by: Ivan Akhrymuk, et al.
Published: (2020-01-01)

Tumour Necrosis Factor-α, Chemokines, and Leukocyte Infiltrate Are Biomarkers for Pathology in the Brains of Venezuelan Equine Encephalitis (VEEV)-Infected Mice
by: Amanda L. Phelps, et al.
Published: (2023-05-01)

Current Understanding of the Molecular Basis of Venezuelan Equine Encephalitis Virus Pathogenesis and Vaccine Development
by: Anuj Sharma, et al.
Published: (2019-02-01)

Specificity Studies of the Venezuelan Equine Encephalitis Virus Non-Structural Protein 2 Protease Using Recombinant Fluorescent Substrates
by: Beáta Bozóki, et al.
Published: (2020-10-01)

Resveratrol Inhibits Venezuelan Equine Encephalitis Virus Infection by Interfering with the AKT/GSK Pathway
by: Caitlin W. Lehman, et al.
Published: (2021-02-01)

Venezuelan Equine Encephalitis and 2 Human Deaths, Peru
by: Stalin Vilcarromero, et al.
Published: (2010-03-01)

First detection of Rio Negro virus (Venezuelan equine encephalitis complex subtype VI) in Córdoba, Argentina
by: María Belén Pisano, et al.
Published: (2012-02-01)

Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3
by: Allison Bakovic, et al.
Published: (2021-08-01)

Inactivation of Venezuelan Equine Encephalitis Virus Genome Using Two Methods
by: Mahgol Behnia, et al.
Published: (2022-01-01)

Letter to the Editor: Venezuelan Equine Encephalitis virus 1B Invasion and Epidemic Control—South Texas, 1971
by: Robert G. McLean
Published: (2020-06-01)

Rationally Attenuated Vaccines for Venezuelan Equine Encephalitis Protect Against Epidemic Strains with a Single Dose
by: Shannan L. Rossi, et al.
Published: (2020-09-01)

EGR1 Upregulation during Encephalitic Viral Infections Contributes to Inflammation and Cell Death
by: Caitlin W. Lehman, et al.
Published: (2022-06-01)

Efficacy of Western, Eastern, and Venezuelan Equine Encephalitis (WEVEE) Virus-Replicon Particle (VRP) Vaccine against WEEV in a Non-Human Primate Animal Model
by: Crystal W. Burke, et al.
Published: (2022-07-01)

Mapping Eastern (EEE) and Venezuelan Equine Encephalitides (VEE) among Equines Using Geographical Information Systems, Colombia, 2008–2019
by: D. Katterine Bonilla-Aldana, et al.
Published: (2023-03-01)

Human transcriptome response to immunization with live-attenuated Venezuelan equine encephalitis virus vaccine (TC-83): Analysis of whole blood
by: Rebecca A. Erwin-Cohen, et al.
Published: (2017-01-01)

Venezuelan equine encephalitis virus: the problem is not over for tropical America
by: Camilo Guzmán-Terán, et al.
Published: (2020-05-01)

Postepizootic Persistence of Venezuelan Equine Encephalitis Virus, Venezuela
by: Juan-Carlos Navarro, et al.
Published: (2005-12-01)

Venezuelan Equine Encephalitis Virus nsP3 Phosphorylation Can Be Mediated by IKKβ Kinase Activity and Abrogation of Phosphorylation Inhibits Negative-Strand Synthesis
by: Allison Bakovic, et al.
Published: (2020-09-01)

PERK Is Critical for Alphavirus Nonstructural Protein Translation
by: Bibha Dahal, et al.
Published: (2021-05-01)

Locally Acquired Eastern Equine Encephalitis Virus Disease, Arkansas, USA
by: Jeremy Garlick, et al.
Published: (2016-12-01)

A Monovalent and Trivalent MVA-Based Vaccine Completely Protects Mice Against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenge
by: Lisa Henning, et al.
Published: (2021-01-01)

In Vitro and In Vivo Phenotypes of Venezuelan, Eastern and Western Equine Encephalitis Viruses Derived from cDNA Clones of Human Isolates
by: Christina L. Gardner, et al.
Published: (2022-12-01)

Venezuelan Equine Encephalitis Virus Infection of Cotton Rats
by: Anne-Sophie Carrara, et al.
Published: (2007-08-01)

The Structural Biology of Eastern Equine Encephalitis Virus, an Emerging Viral Threat
by: S. Saif Hasan, et al.
Published: (2021-07-01)

Differential host gene responses from infection with neurovirulent and partially-neurovirulent strains of Venezuelan equine encephalitis virus
by: Paridhi Gupta, et al.
Published: (2017-04-01)

Engineered Mesenchymal Cells Improve Passive Immune Protection Against Lethal Venezuelan Equine Encephalitis Virus Exposure
by: Lorena R. Braid, et al.
Published: (2016-08-01)

Application of In Silico and HTS Approaches to Identify Nuclear Import Inhibitors for Venezuelan Equine Encephalitis Virus Capsid Protein: A Case Study
by: Sharon Shechter, et al.
Published: (2020-12-01)

The vaccines based on the replicon of the venezuelan equine encephalomyelitis virus against viral hemorrhagic fevers
by: A. A. Petrov, et al.
Published: (2015-06-01)

Aerosol infection of Balb/c mice with eastern equine encephalitis virus; susceptibility and lethality
by: Amanda L. Phelps, et al.
Published: (2019-01-01)

Defining the Cynomolgus Macaque (<i>Macaca fascicularis</i>) Animal Model for Aerosolized Venezuelan Equine Encephalitis: Importance of Challenge Dose and Viral Subtype
by: Crystal W. Burke, et al.
Published: (2023-11-01)