Impact of Carbamazepine Treatment in Testicular Histology in Albino Mice (Mus musculus)
Carbamazepine (CBZ) is an antiepileptic medication (AED) intended to treat epilepsy, although it is also used to treat psychiatric problems and neuropathic pain. CBZ use has been linked to male reproduction problems such as hormonal changes, sexual problems, and sperm quality loss in addition to it...
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| Format: | Article |
| Language: | English |
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University of Baghdad
2023-10-01
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| Series: | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| Subjects: | |
| Online Access: | https://jih.uobaghdad.edu.iq/index.php/j/article/view/3128 |
| _version_ | 1797653930257154048 |
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| author | Zainab Abd-Ali Sabr Zainab Kareem |
| author_facet | Zainab Abd-Ali Sabr Zainab Kareem |
| author_sort | Zainab Abd-Ali Sabr |
| collection | DOAJ |
| description |
Carbamazepine (CBZ) is an antiepileptic medication (AED) intended to treat epilepsy, although it is also used to treat psychiatric problems and neuropathic pain. CBZ use has been linked to male reproduction problems such as hormonal changes, sexual problems, and sperm quality loss in addition to its effect on the hypothalamic-pituitary-gonadal (HPG) axis. The present study aimed to check the potential consequences of carbamazepine on the histology of the testis. In this experiment, 24 adult males of Swiss albino mice were divided into four groups. The control group was gavaged with distilled water, and the others were treated with carbamazepine orally administered with 0.1 ml of a daily dose of concentrations (2.5, 5 and 10) mg/kg bw for 60 consecutive days. Several histological alterations were caused by the therapy in the testis, which included congestion, necrosis, edema, hemorrhage, shrinkage tubule, germ cell shedding, and amyloid.
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| first_indexed | 2024-03-11T16:51:59Z |
| format | Article |
| id | doaj.art-fe464ea1bb4349ff8e6aa3d3e1a0c41b |
| institution | Directory Open Access Journal |
| issn | 1609-4042 2521-3407 |
| language | English |
| last_indexed | 2024-03-11T16:51:59Z |
| publishDate | 2023-10-01 |
| publisher | University of Baghdad |
| record_format | Article |
| series | Ibn Al-Haitham Journal for Pure and Applied Sciences |
| spelling | doaj.art-fe464ea1bb4349ff8e6aa3d3e1a0c41b2023-10-21T06:44:48ZengUniversity of BaghdadIbn Al-Haitham Journal for Pure and Applied Sciences1609-40422521-34072023-10-0136410.30526/36.4.3128Impact of Carbamazepine Treatment in Testicular Histology in Albino Mice (Mus musculus)Zainab Abd-Ali Sabr0Zainab Kareem1Department of Biology College of Science for Women, University of Baghdad, Baghdad, IraqDepartment of biology , College of Science for Women , University of Baghdad, Baghdad, Iraq Carbamazepine (CBZ) is an antiepileptic medication (AED) intended to treat epilepsy, although it is also used to treat psychiatric problems and neuropathic pain. CBZ use has been linked to male reproduction problems such as hormonal changes, sexual problems, and sperm quality loss in addition to its effect on the hypothalamic-pituitary-gonadal (HPG) axis. The present study aimed to check the potential consequences of carbamazepine on the histology of the testis. In this experiment, 24 adult males of Swiss albino mice were divided into four groups. The control group was gavaged with distilled water, and the others were treated with carbamazepine orally administered with 0.1 ml of a daily dose of concentrations (2.5, 5 and 10) mg/kg bw for 60 consecutive days. Several histological alterations were caused by the therapy in the testis, which included congestion, necrosis, edema, hemorrhage, shrinkage tubule, germ cell shedding, and amyloid. https://jih.uobaghdad.edu.iq/index.php/j/article/view/3128Carbamazepine , testis , germ cells , Leydig cells, edema, necrosis |
| spellingShingle | Zainab Abd-Ali Sabr Zainab Kareem Impact of Carbamazepine Treatment in Testicular Histology in Albino Mice (Mus musculus) Ibn Al-Haitham Journal for Pure and Applied Sciences Carbamazepine , testis , germ cells , Leydig cells, edema, necrosis |
| title | Impact of Carbamazepine Treatment in Testicular Histology in Albino Mice (Mus musculus) |
| title_full | Impact of Carbamazepine Treatment in Testicular Histology in Albino Mice (Mus musculus) |
| title_fullStr | Impact of Carbamazepine Treatment in Testicular Histology in Albino Mice (Mus musculus) |
| title_full_unstemmed | Impact of Carbamazepine Treatment in Testicular Histology in Albino Mice (Mus musculus) |
| title_short | Impact of Carbamazepine Treatment in Testicular Histology in Albino Mice (Mus musculus) |
| title_sort | impact of carbamazepine treatment in testicular histology in albino mice mus musculus |
| topic | Carbamazepine , testis , germ cells , Leydig cells, edema, necrosis |
| url | https://jih.uobaghdad.edu.iq/index.php/j/article/view/3128 |
| work_keys_str_mv | AT zainababdalisabr impactofcarbamazepinetreatmentintesticularhistologyinalbinomicemusmusculus AT zainabkareem impactofcarbamazepinetreatmentintesticularhistologyinalbinomicemusmusculus |