An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking
The cytosolic tail of β-coronavirus spike proteins contains dibasic motifs that must be able to bind to the host’s coatomer protein-I (COPI) for trafficking and be released for viral assembly in the ER-Golgi intermediate compartment. The critical residues in both the spike cytosolic tail and COPI ar...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03063-y |