TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults
HIV-patients have excess of pneumococcal infection. We immunized 40 HIV-patients twice with pneumococcal conjugate vaccine (Prevnar, Pfizer) +/− a TLR9 agonist (CPG 7909). Peripheral blood mononuclear cells were stimulated with pneumococcal polysaccharides and cytokine concentrations measured. The C...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2012-08-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.4161/hv.20707 |
| _version_ | 1797633036113674240 |
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| author | Rasmus Offersen Jesper Melchjorsen Søren R. Paludan Lars Østergaard Martin Tolstrup Ole S. Søgaard |
| author_facet | Rasmus Offersen Jesper Melchjorsen Søren R. Paludan Lars Østergaard Martin Tolstrup Ole S. Søgaard |
| author_sort | Rasmus Offersen |
| collection | DOAJ |
| description | HIV-patients have excess of pneumococcal infection. We immunized 40 HIV-patients twice with pneumococcal conjugate vaccine (Prevnar, Pfizer) +/− a TLR9 agonist (CPG 7909). Peripheral blood mononuclear cells were stimulated with pneumococcal polysaccharides and cytokine concentrations measured. The CPG 7909 adjuvant group had significantly higher relative cytokine responses than the placebo group for IL-1β, IL-2R, IL-6, IFN-γ and MIP-β, which, did not correlate with IgG antibody responses. These findings suggests that CPG 7909 as adjuvant to pneumococcal conjugate vaccine induces cellular memory to pneumococcal polysaccharides in HIV-patients, independently of the humoral response. |
| first_indexed | 2024-03-11T11:45:10Z |
| format | Article |
| id | doaj.art-fe47c4b825874cc083b16b8b4f10e9b6 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T11:45:10Z |
| publishDate | 2012-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-fe47c4b825874cc083b16b8b4f10e9b62023-11-09T15:17:18ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2012-08-01881042104710.4161/hv.20707TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adultsRasmus Offersen0Jesper Melchjorsen1Søren R. Paludan2Lars Østergaard3Martin Tolstrup4Ole S. Søgaard5Department of Infectious Diseases; Aarhus University Hospital; Aarhus, DenmarkDepartment of Infectious Diseases; Aarhus University Hospital; Aarhus, DenmarkDepartment of Biomedicine; Aarhus University; Aarhus, DenmarkDepartment of Infectious Diseases; Aarhus University Hospital; Aarhus, DenmarkDepartment of Infectious Diseases; Aarhus University Hospital; Aarhus, DenmarkDepartment of Infectious Diseases; Aarhus University Hospital; Aarhus, DenmarkHIV-patients have excess of pneumococcal infection. We immunized 40 HIV-patients twice with pneumococcal conjugate vaccine (Prevnar, Pfizer) +/− a TLR9 agonist (CPG 7909). Peripheral blood mononuclear cells were stimulated with pneumococcal polysaccharides and cytokine concentrations measured. The CPG 7909 adjuvant group had significantly higher relative cytokine responses than the placebo group for IL-1β, IL-2R, IL-6, IFN-γ and MIP-β, which, did not correlate with IgG antibody responses. These findings suggests that CPG 7909 as adjuvant to pneumococcal conjugate vaccine induces cellular memory to pneumococcal polysaccharides in HIV-patients, independently of the humoral response.https://www.tandfonline.com/doi/10.4161/hv.20707pneumococcal vaccinecellular memoryCpG-ODNadjuvantsHIVTLR9 |
| spellingShingle | Rasmus Offersen Jesper Melchjorsen Søren R. Paludan Lars Østergaard Martin Tolstrup Ole S. Søgaard TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults Human Vaccines & Immunotherapeutics pneumococcal vaccine cellular memory CpG-ODN adjuvants HIV TLR9 |
| title | TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults |
| title_full | TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults |
| title_fullStr | TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults |
| title_full_unstemmed | TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults |
| title_short | TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults |
| title_sort | tlr9 adjuvanted pneumococcal conjugate vaccine induces antibody independent memory responses in hiv infected adults |
| topic | pneumococcal vaccine cellular memory CpG-ODN adjuvants HIV TLR9 |
| url | https://www.tandfonline.com/doi/10.4161/hv.20707 |
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