TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults

TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults

HIV-patients have excess of pneumococcal infection. We immunized 40 HIV-patients twice with pneumococcal conjugate vaccine (Prevnar, Pfizer) +/− a TLR9 agonist (CPG 7909). Peripheral blood mononuclear cells were stimulated with pneumococcal polysaccharides and cytokine concentrations measured. The C...

Full description

Bibliographic Details
Main Authors: Rasmus Offersen, Jesper Melchjorsen, Søren R. Paludan, Lars Østergaard, Martin Tolstrup, Ole S. Søgaard
Format: Article
Language:English
Published: Taylor & Francis Group 2012-08-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
pneumococcal vaccine
cellular memory
CpG-ODN
adjuvants
HIV
TLR9
Online Access:https://www.tandfonline.com/doi/10.4161/hv.20707

Similar Items

Similar Items