Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini Review
Reproductive dysfunction is often characterized by malfunction of the reproductive tissues, which may lead to disruption of the synergistic rhythm that should bring about a progression of sexual events and the conception of new life. This may therefore result in the sexual dysfunction and infertilit...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/8/1/7 |
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| author | Omowumi T. Kayode Damilare E. Rotimi Abolanle A. A. Kayode Tomilola D. Olaolu Oluyomi S. Adeyemi |
| author_facet | Omowumi T. Kayode Damilare E. Rotimi Abolanle A. A. Kayode Tomilola D. Olaolu Oluyomi S. Adeyemi |
| author_sort | Omowumi T. Kayode |
| collection | DOAJ |
| description | Reproductive dysfunction is often characterized by malfunction of the reproductive tissues, which may lead to disruption of the synergistic rhythm that should bring about a progression of sexual events and the conception of new life. This may therefore result in the sexual dysfunction and infertility that can be seen in couples having prolonged biological difficulty in reproducing their offspring after having unrestricted sexual intercourse for at least twelve months. Several factors have been implicated in the cause and progression of reproductive dysfunction, including poor nutrition, drug side effects, disease states, and toxicant ingestion. A well-known food additive that has been found to be potent at initiating reproductive anomalies in males is monosodium glutamate (MSG). This regular flavor enhancer is widely used as a taste enhancer in several diets. The different mechanisms by which it may induce reproductive dysfunctions include spermatogenic alteration resulting in a low sperm count, high sperm abnormality, reduced live sperm and decreased sperm pH, oxidative damage (increased lipid peroxidation and reduced antioxidant enzyme activities), histological alteration (blood hemorrhage, distorted germ and Sertoli cells), as well as gonadotropin imbalance (reduced testosterone, luteinizing hormone, and follicle-stimulating hormone concentrations). Therefore, this review discusses various established mechanisms through which MSG may induce reproductive dysfunction and the treatment strategies to ameliorate its toxic effects. |
| first_indexed | 2024-12-10T23:50:43Z |
| format | Article |
| id | doaj.art-fe4899580a674170ae3948c36709ccd3 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-12-10T23:50:43Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-fe4899580a674170ae3948c36709ccd32022-12-22T01:28:46ZengMDPI AGToxics2305-63042020-01-0181710.3390/toxics8010007toxics8010007Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini ReviewOmowumi T. Kayode0Damilare E. Rotimi1Abolanle A. A. Kayode2Tomilola D. Olaolu3Oluyomi S. Adeyemi4Department of Biochemistry, College of Pure and Applied Sciences, Landmark University, P.M.B 1001, Omu Aran 251101, NigeriaDepartment of Biochemistry, College of Pure and Applied Sciences, Landmark University, P.M.B 1001, Omu Aran 251101, NigeriaDepartment of Chemical Sciences, Faculty of Science and Science Education, Anchor University, P.M.B 001, Ipaja, NigeriaDepartment of Biochemistry, College of Pure and Applied Sciences, Landmark University, P.M.B 1001, Omu Aran 251101, NigeriaDepartment of Biochemistry, College of Pure and Applied Sciences, Landmark University, P.M.B 1001, Omu Aran 251101, NigeriaReproductive dysfunction is often characterized by malfunction of the reproductive tissues, which may lead to disruption of the synergistic rhythm that should bring about a progression of sexual events and the conception of new life. This may therefore result in the sexual dysfunction and infertility that can be seen in couples having prolonged biological difficulty in reproducing their offspring after having unrestricted sexual intercourse for at least twelve months. Several factors have been implicated in the cause and progression of reproductive dysfunction, including poor nutrition, drug side effects, disease states, and toxicant ingestion. A well-known food additive that has been found to be potent at initiating reproductive anomalies in males is monosodium glutamate (MSG). This regular flavor enhancer is widely used as a taste enhancer in several diets. The different mechanisms by which it may induce reproductive dysfunctions include spermatogenic alteration resulting in a low sperm count, high sperm abnormality, reduced live sperm and decreased sperm pH, oxidative damage (increased lipid peroxidation and reduced antioxidant enzyme activities), histological alteration (blood hemorrhage, distorted germ and Sertoli cells), as well as gonadotropin imbalance (reduced testosterone, luteinizing hormone, and follicle-stimulating hormone concentrations). Therefore, this review discusses various established mechanisms through which MSG may induce reproductive dysfunction and the treatment strategies to ameliorate its toxic effects.https://www.mdpi.com/2305-6304/8/1/7antioxidant enzymesmonosodium glutamatereactive oxygen speciesreproductive dysfunctionsperm qualitytestosterone |
| spellingShingle | Omowumi T. Kayode Damilare E. Rotimi Abolanle A. A. Kayode Tomilola D. Olaolu Oluyomi S. Adeyemi Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini Review Toxics antioxidant enzymes monosodium glutamate reactive oxygen species reproductive dysfunction sperm quality testosterone |
| title | Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini Review |
| title_full | Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini Review |
| title_fullStr | Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini Review |
| title_full_unstemmed | Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini Review |
| title_short | Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini Review |
| title_sort | monosodium glutamate msg induced male reproductive dysfunction a mini review |
| topic | antioxidant enzymes monosodium glutamate reactive oxygen species reproductive dysfunction sperm quality testosterone |
| url | https://www.mdpi.com/2305-6304/8/1/7 |
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