Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites
Most of the disease studies for the gut microbiome have collected cases and control samples from the elderly or the middle-aged. Despite general interest in microbiome health, it is not known how microbial biomarkers from metagenome-wide association studies (MWAS) would perform in a cohort of young...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Medicine in Microecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590097821000057 |
| _version_ | 1818936680733736960 |
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| author | Zhuye Jie Suisha Liang Qiuxia Ding Fei Li Xiaohuan Sun Yuxiang Lin Peishan Chen Kaiye Cai Hongcheng Zhou Haorong Lu Xiaohan Wang Tao Zhang Liang Xiao Huanming Yang Jian Wang Yong Hou Karsten Kristiansen Huijue Jia Xun Xu |
| author_facet | Zhuye Jie Suisha Liang Qiuxia Ding Fei Li Xiaohuan Sun Yuxiang Lin Peishan Chen Kaiye Cai Hongcheng Zhou Haorong Lu Xiaohan Wang Tao Zhang Liang Xiao Huanming Yang Jian Wang Yong Hou Karsten Kristiansen Huijue Jia Xun Xu |
| author_sort | Zhuye Jie |
| collection | DOAJ |
| description | Most of the disease studies for the gut microbiome have collected cases and control samples from the elderly or the middle-aged. Despite general interest in microbiome health, it is not known how microbial biomarkers from metagenome-wide association studies (MWAS) would perform in a cohort of young individuals, who would be largely free of chronic diseases, as well as medication. Here we analyze high-depth fecal metagenomic shotgun sequencing for 2183 healthy adults with clinical parameters, diet, lifestyle, and metabolite measurements. We provide the first set of large-scale evidence for gut microbiome dysbiosis in hyperuricemia, which relates to meat intake. We build a cardiometabolic disease risk model based on gut microbes for initial screening in a young population and confirm the validity using external cohorts. Fecal bacteria that have been reported to be enriched in colorectal cancer (CRC) are found to correlate with methylhistidines, branched-chain amino acids (BCAA), aromatic amino acids and glutamic acid in these young individuals, which were validated by an additional cohort of 1404 individuals. Our comprehensive data suggest that the gut microbiome could show trends towards diseases years before onset, and the results lay the foundation for the design of larger screens for cardiometabolic diseases and CRC with clinically meaningful cutoffs. |
| first_indexed | 2024-12-20T05:39:55Z |
| format | Article |
| id | doaj.art-fe4a64158b1343a4bf5530aeff09bd33 |
| institution | Directory Open Access Journal |
| issn | 2590-0978 |
| language | English |
| last_indexed | 2024-12-20T05:39:55Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Microecology |
| spelling | doaj.art-fe4a64158b1343a4bf5530aeff09bd332022-12-21T19:51:30ZengElsevierMedicine in Microecology2590-09782021-09-019100037Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolitesZhuye Jie0Suisha Liang1Qiuxia Ding2Fei Li3Xiaohuan Sun4Yuxiang Lin5Peishan Chen6Kaiye Cai7Hongcheng Zhou8Haorong Lu9Xiaohan Wang10Tao Zhang11Liang Xiao12Huanming Yang13Jian Wang14Yong Hou15Karsten Kristiansen16Huijue Jia17Xun Xu18BGI-Shenzhen, Shenzhen, China; Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, BGI-Shenzhen, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Universitetsparken 13, University of Copenhagen, Copenhagen, Denmark; Corresponding author. BGI-Shenzhen, Shenzhen, China.BGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, ChinaChina National Genebank, BGI-Shenzhen, Shenzhen, 518120, ChinaChina National Genebank, BGI-Shenzhen, Shenzhen, 518120, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Universitetsparken 13, University of Copenhagen, Copenhagen, DenmarkBGI-Shenzhen, Shenzhen, China; Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome, BGI-Shenzhen, Shenzhen, China; BGI-Qingdao, BGI-Shenzhen, Qingdao, 266555, ChinaBGI-Shenzhen, Shenzhen, China; James D. Watson Institute of Genome Sciences, Hangzhou, ChinaBGI-Shenzhen, Shenzhen, China; James D. Watson Institute of Genome Sciences, Hangzhou, ChinaBGI-Shenzhen, Shenzhen, ChinaBGI-Shenzhen, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Universitetsparken 13, University of Copenhagen, Copenhagen, Denmark; BGI-Qingdao, BGI-Shenzhen, Qingdao, 266555, ChinaBGI-Shenzhen, Shenzhen, China; Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, BGI-Shenzhen, Shenzhen, China; Laboratory of Genomics and Molecular Biomedicine, Department of Biology, Universitetsparken 13, University of Copenhagen, Copenhagen, Denmark; Corresponding author. BGI-Shenzhen, Shenzhen, China.BGI-Shenzhen, Shenzhen, ChinaMost of the disease studies for the gut microbiome have collected cases and control samples from the elderly or the middle-aged. Despite general interest in microbiome health, it is not known how microbial biomarkers from metagenome-wide association studies (MWAS) would perform in a cohort of young individuals, who would be largely free of chronic diseases, as well as medication. Here we analyze high-depth fecal metagenomic shotgun sequencing for 2183 healthy adults with clinical parameters, diet, lifestyle, and metabolite measurements. We provide the first set of large-scale evidence for gut microbiome dysbiosis in hyperuricemia, which relates to meat intake. We build a cardiometabolic disease risk model based on gut microbes for initial screening in a young population and confirm the validity using external cohorts. Fecal bacteria that have been reported to be enriched in colorectal cancer (CRC) are found to correlate with methylhistidines, branched-chain amino acids (BCAA), aromatic amino acids and glutamic acid in these young individuals, which were validated by an additional cohort of 1404 individuals. Our comprehensive data suggest that the gut microbiome could show trends towards diseases years before onset, and the results lay the foundation for the design of larger screens for cardiometabolic diseases and CRC with clinically meaningful cutoffs.http://www.sciencedirect.com/science/article/pii/S2590097821000057Gut microbiomeShotgun sequencingMulti-omicYoung individualsUric acidDisease |
| spellingShingle | Zhuye Jie Suisha Liang Qiuxia Ding Fei Li Xiaohuan Sun Yuxiang Lin Peishan Chen Kaiye Cai Hongcheng Zhou Haorong Lu Xiaohan Wang Tao Zhang Liang Xiao Huanming Yang Jian Wang Yong Hou Karsten Kristiansen Huijue Jia Xun Xu Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites Medicine in Microecology Gut microbiome Shotgun sequencing Multi-omic Young individuals Uric acid Disease |
| title | Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites |
| title_full | Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites |
| title_fullStr | Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites |
| title_full_unstemmed | Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites |
| title_short | Disease trends in a young Chinese cohort according to fecal metagenome and plasma metabolites |
| title_sort | disease trends in a young chinese cohort according to fecal metagenome and plasma metabolites |
| topic | Gut microbiome Shotgun sequencing Multi-omic Young individuals Uric acid Disease |
| url | http://www.sciencedirect.com/science/article/pii/S2590097821000057 |
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