Cirrhosis of Liver and Diabetes Mellitus: The Diabolic Duo?
Introduction: Cirrhosis of the liver and diabetes mellitus are two chronic illnesses with significant impact on the quality of life. Studies from different part of the world have shown the combination to be associated with higher incidence of complications of cirrhosis and reduced survival. Howe...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2017-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/10529/30705_CE[RA1]_F[AP]_PF1(NE_VT_GG)_PFA(NE_SS).pdf |
| _version_ | 1811283715724148736 |
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| author | Thazhath Mavali Ramachandran Aninchent Harayil Rajan Rajneesh George Sarin Zacharia Rajendran P Adarsh |
| author_facet | Thazhath Mavali Ramachandran Aninchent Harayil Rajan Rajneesh George Sarin Zacharia Rajendran P Adarsh |
| author_sort | Thazhath Mavali Ramachandran |
| collection | DOAJ |
| description | Introduction: Cirrhosis of the liver and diabetes mellitus are
two chronic illnesses with significant impact on the quality
of life. Studies from different part of the world have shown
the combination to be associated with higher incidence of
complications of cirrhosis and reduced survival. However, data
on the impact of pre-cirrhotic and post-cirrhotic diabetes on
cirrhosis is minimal.
Aim: The aim of the study was to determine the complications
of cirrhosis patients with and without co-existent DM and to
compare the relation between cirrhosis patients with antecedent
DM and hepatogenous DM.
Materials and Methods: The present prospective study was
conducted at a tertiary care hospital in Kerala, India, over
a period of three years. Cirrhosis patients with and without
diabetes, along with subcategorization as antecedent and
hepatogenous diabetes, were studied for various complications
and outcome including death. Chi-square and Mann-whitney
tests were used for comparing data.
Results: Patients with cirrhosis and diabetes had higher
incidence of gall stones (27.6% versus 13.2%; p=0.008) and
urinary infection (29.3% versus 7.5%; p=<0.001). Incidence of
hepatocellular carcinoma and mortality were similar between the
groups. Patients with antecedent diabetes and hepatogenous
diabetes were similar with respect to complications and
mortality. Child-Turcotte-Pugh (CTP) score, Model for End
stage Liver Disease (MELD) score, urinary tract and respiratory
infections and duration of cirrhosis were independent predictors
of mortality in patients with cirrhosis.
Conclusion: Coexistent diabetes mellitus increases the
incidence of complications and hospitalizations in cirrhosis
patients but without impact on mortality rates. There is no
significant morbidity or mortality difference between cirrhotics
with antecedent diabetes and hepatogenous diabetes. |
| first_indexed | 2024-04-13T02:17:39Z |
| format | Article |
| id | doaj.art-fe4b0e9a80fe494f8d33427092c3ac5a |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-13T02:17:39Z |
| publishDate | 2017-09-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-fe4b0e9a80fe494f8d33427092c3ac5a2022-12-22T03:07:07ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-09-01119OC01OC0510.7860/JCDR/2017/30705.10529Cirrhosis of Liver and Diabetes Mellitus: The Diabolic Duo?Thazhath Mavali Ramachandran0Aninchent Harayil Rajan Rajneesh1George Sarin Zacharia2Rajendran P Adarsh3Additional Professor, Department of Medical Gastroenterology, Government Medical College, Kozhikode, Kerala, India.Senior Resident, Department of Medical Gastroenterology, Government Medical College, Kozhikode, Kerala, India.Senior Resident, Department of Medical Gastroenterology, Government Medical College, Kozhikode, Kerala, India.Senior Resident, Department of Medical Gastroenterology, Government Medical College, Kozhikode, Kerala, India.Introduction: Cirrhosis of the liver and diabetes mellitus are two chronic illnesses with significant impact on the quality of life. Studies from different part of the world have shown the combination to be associated with higher incidence of complications of cirrhosis and reduced survival. However, data on the impact of pre-cirrhotic and post-cirrhotic diabetes on cirrhosis is minimal. Aim: The aim of the study was to determine the complications of cirrhosis patients with and without co-existent DM and to compare the relation between cirrhosis patients with antecedent DM and hepatogenous DM. Materials and Methods: The present prospective study was conducted at a tertiary care hospital in Kerala, India, over a period of three years. Cirrhosis patients with and without diabetes, along with subcategorization as antecedent and hepatogenous diabetes, were studied for various complications and outcome including death. Chi-square and Mann-whitney tests were used for comparing data. Results: Patients with cirrhosis and diabetes had higher incidence of gall stones (27.6% versus 13.2%; p=0.008) and urinary infection (29.3% versus 7.5%; p=<0.001). Incidence of hepatocellular carcinoma and mortality were similar between the groups. Patients with antecedent diabetes and hepatogenous diabetes were similar with respect to complications and mortality. Child-Turcotte-Pugh (CTP) score, Model for End stage Liver Disease (MELD) score, urinary tract and respiratory infections and duration of cirrhosis were independent predictors of mortality in patients with cirrhosis. Conclusion: Coexistent diabetes mellitus increases the incidence of complications and hospitalizations in cirrhosis patients but without impact on mortality rates. There is no significant morbidity or mortality difference between cirrhotics with antecedent diabetes and hepatogenous diabetes.https://jcdr.net/articles/PDF/10529/30705_CE[RA1]_F[AP]_PF1(NE_VT_GG)_PFA(NE_SS).pdfcarcinomacomplicationshepatocellularurinary tract infection |
| spellingShingle | Thazhath Mavali Ramachandran Aninchent Harayil Rajan Rajneesh George Sarin Zacharia Rajendran P Adarsh Cirrhosis of Liver and Diabetes Mellitus: The Diabolic Duo? Journal of Clinical and Diagnostic Research carcinoma complications hepatocellular urinary tract infection |
| title | Cirrhosis of Liver and Diabetes Mellitus: The Diabolic Duo? |
| title_full | Cirrhosis of Liver and Diabetes Mellitus: The Diabolic Duo? |
| title_fullStr | Cirrhosis of Liver and Diabetes Mellitus: The Diabolic Duo? |
| title_full_unstemmed | Cirrhosis of Liver and Diabetes Mellitus: The Diabolic Duo? |
| title_short | Cirrhosis of Liver and Diabetes Mellitus: The Diabolic Duo? |
| title_sort | cirrhosis of liver and diabetes mellitus the diabolic duo |
| topic | carcinoma complications hepatocellular urinary tract infection |
| url | https://jcdr.net/articles/PDF/10529/30705_CE[RA1]_F[AP]_PF1(NE_VT_GG)_PFA(NE_SS).pdf |
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