NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity
The innate immune system recognizes pathogen-associated molecular motifs through pattern recognition receptors (PRRs) that induce inflammasome assembly in macrophages and trigger signal transduction pathways, thereby leading to the transcription of inflammatory cytokine genes. Nucleotide-binding oli...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/9/1487 |
| _version_ | 1797481593893289984 |
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| author | Magdalena Godkowicz Magdalena Druszczyńska |
| author_facet | Magdalena Godkowicz Magdalena Druszczyńska |
| author_sort | Magdalena Godkowicz |
| collection | DOAJ |
| description | The innate immune system recognizes pathogen-associated molecular motifs through pattern recognition receptors (PRRs) that induce inflammasome assembly in macrophages and trigger signal transduction pathways, thereby leading to the transcription of inflammatory cytokine genes. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) represent a family of cytosolic PRRs involved in the detection of intracellular pathogens such as mycobacteria or viruses. In this review, we discuss the role of NOD1, NOD2, and NLRC5 receptors in regulating antiviral and antimycobacterial immune responses by providing insight into molecular mechanisms as well as their potential health and disease implications. |
| first_indexed | 2024-03-09T22:16:50Z |
| format | Article |
| id | doaj.art-fe4e5a42c1ea443e940967170dc96958 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T22:16:50Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-fe4e5a42c1ea443e940967170dc969582023-11-23T19:21:57ZengMDPI AGVaccines2076-393X2022-09-01109148710.3390/vaccines10091487NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial ImmunityMagdalena Godkowicz0Magdalena Druszczyńska1Lodz Institutes of the Polish Academy of Sciences, The Bio-Med-Chem Doctoral School, University of Lodz, 90-237 Lodz, PolandDepartment of Immunology and Infectious Biology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha12/16, 90-237 Lodz, PolandThe innate immune system recognizes pathogen-associated molecular motifs through pattern recognition receptors (PRRs) that induce inflammasome assembly in macrophages and trigger signal transduction pathways, thereby leading to the transcription of inflammatory cytokine genes. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) represent a family of cytosolic PRRs involved in the detection of intracellular pathogens such as mycobacteria or viruses. In this review, we discuss the role of NOD1, NOD2, and NLRC5 receptors in regulating antiviral and antimycobacterial immune responses by providing insight into molecular mechanisms as well as their potential health and disease implications.https://www.mdpi.com/2076-393X/10/9/1487NLRantimicrobial immunityssRNA virus |
| spellingShingle | Magdalena Godkowicz Magdalena Druszczyńska NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity Vaccines NLR antimicrobial immunity ssRNA virus |
| title | NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity |
| title_full | NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity |
| title_fullStr | NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity |
| title_full_unstemmed | NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity |
| title_short | NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity |
| title_sort | nod1 nod2 and nlrc5 receptors in antiviral and antimycobacterial immunity |
| topic | NLR antimicrobial immunity ssRNA virus |
| url | https://www.mdpi.com/2076-393X/10/9/1487 |
| work_keys_str_mv | AT magdalenagodkowicz nod1nod2andnlrc5receptorsinantiviralandantimycobacterialimmunity AT magdalenadruszczynska nod1nod2andnlrc5receptorsinantiviralandantimycobacterialimmunity |