Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathway
The MetE like complex is found to be capable of regulating the PKS system to produce EPA in Schizochytrium, with its activation regulating the expression of key enzymes, improving the efficiency of DHA and EPA production.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-04334-4 |
| _version_ | 1828121117130227712 |
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| author | Wang Ma Mengzhen Liu Zixu Zhang Yingshuang Xu Pengwei Huang Dongsheng Guo Xiaoman Sun He Huang |
| author_facet | Wang Ma Mengzhen Liu Zixu Zhang Yingshuang Xu Pengwei Huang Dongsheng Guo Xiaoman Sun He Huang |
| author_sort | Wang Ma |
| collection | DOAJ |
| description | The MetE like complex is found to be capable of regulating the PKS system to produce EPA in Schizochytrium, with its activation regulating the expression of key enzymes, improving the efficiency of DHA and EPA production. |
| first_indexed | 2024-04-11T14:16:21Z |
| format | Article |
| id | doaj.art-fe4f2e9f358a4b8aab4edf07df63d604 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-11T14:16:21Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-fe4f2e9f358a4b8aab4edf07df63d6042022-12-22T04:19:25ZengNature PortfolioCommunications Biology2399-36422022-12-015111110.1038/s42003-022-04334-4Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathwayWang Ma0Mengzhen Liu1Zixu Zhang2Yingshuang Xu3Pengwei Huang4Dongsheng Guo5Xiaoman Sun6He Huang7School of Food Science and Pharmaceutical Engineering, Nanjing Normal UniversitySchool of Food Science and Pharmaceutical Engineering, Nanjing Normal UniversitySchool of Food Science and Pharmaceutical Engineering, Nanjing Normal UniversitySchool of Food Science and Pharmaceutical Engineering, Nanjing Normal UniversitySchool of Food Science and Pharmaceutical Engineering, Nanjing Normal UniversitySchool of Food Science and Pharmaceutical Engineering, Nanjing Normal UniversitySchool of Food Science and Pharmaceutical Engineering, Nanjing Normal UniversitySchool of Food Science and Pharmaceutical Engineering, Nanjing Normal UniversityThe MetE like complex is found to be capable of regulating the PKS system to produce EPA in Schizochytrium, with its activation regulating the expression of key enzymes, improving the efficiency of DHA and EPA production.https://doi.org/10.1038/s42003-022-04334-4 |
| spellingShingle | Wang Ma Mengzhen Liu Zixu Zhang Yingshuang Xu Pengwei Huang Dongsheng Guo Xiaoman Sun He Huang Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathway Communications Biology |
| title | Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathway |
| title_full | Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathway |
| title_fullStr | Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathway |
| title_full_unstemmed | Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathway |
| title_short | Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathway |
| title_sort | efficient co production of epa and dha by schizochytrium sp via regulation of the polyketide synthase pathway |
| url | https://doi.org/10.1038/s42003-022-04334-4 |
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