Xiaotan Sanjie Fang prevents colonic inflammation‐related tumorigenesis by inhibiting COX‐2/VEGF expression cancer
Abstract Colitis‐associated bowel cancer (CAC) is one of the most common malignancies associated with inflammation. The aim of this study was to observe a new herbal formula “Xiaotan Sanjie Fang” (XTSJF) derived from the addition and subtraction theory of traditional medicine as an alternative to CA...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Precision Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/prm2.12116 |
| _version_ | 1797390719946588160 |
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| author | Min Ye Jiaqi Du Dagui Chen Lijuan Xiu Xuan Liu Dazhi Sun Xiaowei Wang |
| author_facet | Min Ye Jiaqi Du Dagui Chen Lijuan Xiu Xuan Liu Dazhi Sun Xiaowei Wang |
| author_sort | Min Ye |
| collection | DOAJ |
| description | Abstract Colitis‐associated bowel cancer (CAC) is one of the most common malignancies associated with inflammation. The aim of this study was to observe a new herbal formula “Xiaotan Sanjie Fang” (XTSJF) derived from the addition and subtraction theory of traditional medicine as an alternative to CAC treatment by “Daotan Decoction” and “Xiaojianzhong Decoction”, which are famous traditional Chinese medicine prescriptions for the treatment of inflammatory diseases of the digestive tract. We constructed a DMH/DSS inflammation‐associated colorectal cancer rat model and treated CAC rats with sulfasalazine and different doses of XTSJF. The results showed that the body weight of rats treated with different doses of XTSJF increased, which was still lower than that of normal rats; AFC decreased significantly compared with the model group and the positive control group, and the final dose was superior to the low dose; histological observation revealed that it could maintain the normal structure of colon tissue, while it could inhibit the secretion of VEGF, COX2, and AQP1 and the expression of pro‐inflammatory cytokines IL‐6, IL‐1β, and TNF‐α, promote the expression of caspase‐3 and BAX and inhibit the expression of Bcl‐2. Taken together, these data suggest that XTSJF can inhibit COX‐2/VEGF expression to prevent the development of inflammation‐associated colorectal cancer. |
| first_indexed | 2024-03-08T23:21:24Z |
| format | Article |
| id | doaj.art-fe51beeb3d1f47849243273ec3091c66 |
| institution | Directory Open Access Journal |
| issn | 2642-2514 |
| language | English |
| last_indexed | 2024-03-08T23:21:24Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Precision Medical Sciences |
| spelling | doaj.art-fe51beeb3d1f47849243273ec3091c662023-12-15T05:14:28ZengWileyPrecision Medical Sciences2642-25142023-12-0112425325910.1002/prm2.12116Xiaotan Sanjie Fang prevents colonic inflammation‐related tumorigenesis by inhibiting COX‐2/VEGF expression cancerMin Ye0Jiaqi Du1Dagui Chen2Lijuan Xiu3Xuan Liu4Dazhi Sun5Xiaowei Wang6Department of Traditional Chinese Medicine Second Affiliated Hospital of Naval Medical University Shanghai ChinaDepartment of Anorectal, Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai ChinaInstitute of Translational Medicine Shanghai University Shanghai ChinaDepartment of Traditional Chinese Medicine Second Affiliated Hospital of Naval Medical University Shanghai ChinaDepartment of Traditional Chinese Medicine Second Affiliated Hospital of Naval Medical University Shanghai ChinaDepartment of Traditional Chinese Medicine Second Affiliated Hospital of Naval Medical University Shanghai ChinaDepartment of Traditional Chinese Medicine Second Affiliated Hospital of Naval Medical University Shanghai ChinaAbstract Colitis‐associated bowel cancer (CAC) is one of the most common malignancies associated with inflammation. The aim of this study was to observe a new herbal formula “Xiaotan Sanjie Fang” (XTSJF) derived from the addition and subtraction theory of traditional medicine as an alternative to CAC treatment by “Daotan Decoction” and “Xiaojianzhong Decoction”, which are famous traditional Chinese medicine prescriptions for the treatment of inflammatory diseases of the digestive tract. We constructed a DMH/DSS inflammation‐associated colorectal cancer rat model and treated CAC rats with sulfasalazine and different doses of XTSJF. The results showed that the body weight of rats treated with different doses of XTSJF increased, which was still lower than that of normal rats; AFC decreased significantly compared with the model group and the positive control group, and the final dose was superior to the low dose; histological observation revealed that it could maintain the normal structure of colon tissue, while it could inhibit the secretion of VEGF, COX2, and AQP1 and the expression of pro‐inflammatory cytokines IL‐6, IL‐1β, and TNF‐α, promote the expression of caspase‐3 and BAX and inhibit the expression of Bcl‐2. Taken together, these data suggest that XTSJF can inhibit COX‐2/VEGF expression to prevent the development of inflammation‐associated colorectal cancer.https://doi.org/10.1002/prm2.12116apoptosiscolitis‐associated bowel cancercox‐2/VEGF expressiontraditional Chinese medicineXiaotan Sanjie Fang |
| spellingShingle | Min Ye Jiaqi Du Dagui Chen Lijuan Xiu Xuan Liu Dazhi Sun Xiaowei Wang Xiaotan Sanjie Fang prevents colonic inflammation‐related tumorigenesis by inhibiting COX‐2/VEGF expression cancer Precision Medical Sciences apoptosis colitis‐associated bowel cancer cox‐2/VEGF expression traditional Chinese medicine Xiaotan Sanjie Fang |
| title | Xiaotan Sanjie Fang prevents colonic inflammation‐related tumorigenesis by inhibiting COX‐2/VEGF expression cancer |
| title_full | Xiaotan Sanjie Fang prevents colonic inflammation‐related tumorigenesis by inhibiting COX‐2/VEGF expression cancer |
| title_fullStr | Xiaotan Sanjie Fang prevents colonic inflammation‐related tumorigenesis by inhibiting COX‐2/VEGF expression cancer |
| title_full_unstemmed | Xiaotan Sanjie Fang prevents colonic inflammation‐related tumorigenesis by inhibiting COX‐2/VEGF expression cancer |
| title_short | Xiaotan Sanjie Fang prevents colonic inflammation‐related tumorigenesis by inhibiting COX‐2/VEGF expression cancer |
| title_sort | xiaotan sanjie fang prevents colonic inflammation related tumorigenesis by inhibiting cox 2 vegf expression cancer |
| topic | apoptosis colitis‐associated bowel cancer cox‐2/VEGF expression traditional Chinese medicine Xiaotan Sanjie Fang |
| url | https://doi.org/10.1002/prm2.12116 |
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