A Preoperative Scoring System to Predict the Risk of Inadequate Lymph Node Count in Rectal Cancer
PurposeThe aim of this study was to develop and validate a preoperative scoring system to stratify rectal cancer (RC) patients with different risks of inadequate lymph node examination.MethodsA total of 1,375 stage I–III RC patients between 2011 and 2020 from the Second Affiliated Hospital of Harbin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.938996/full |
| _version_ | 1828305900485476352 |
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| author | Hao Zhang Chunlin Wang Yunxiao Liu Hanqing Hu Guiyu Wang |
| author_facet | Hao Zhang Chunlin Wang Yunxiao Liu Hanqing Hu Guiyu Wang |
| author_sort | Hao Zhang |
| collection | DOAJ |
| description | PurposeThe aim of this study was to develop and validate a preoperative scoring system to stratify rectal cancer (RC) patients with different risks of inadequate lymph node examination.MethodsA total of 1,375 stage I–III RC patients between 2011 and 2020 from the Second Affiliated Hospital of Harbin Medical University were included in the retrospective study and randomly divided into a development set (n = 688) and a validation set (n = 687). The logistic regression model was used to determine independent factors contributing to lymph node count (LNC) < 12. A preoperative scoring system was constructed based on beta (β) coefficients. The area under the receiver operating curve (AUC) was used to test model discrimination.ResultsPreoperative significant indicators related to LNC < 12 included age, tumor size, tumor location, and CEA. The AUCs of the scoring system for development and validation sets were 0.694 (95% CI = 0.648–0.741) and 0.666 (95% CI = 0.615–0.716), respectively. Patients who scored 0–2, 3–4, and 5–6 were classified into the low-risk group, medium-risk group, and high-risk group, respectively.ConclusionsThe preoperative scoring system could identify RC patients with high risk of inadequate lymphadenectomy accurately and further provide a reference to perform preoperative lymph node staining in targeted patients to reduce the difficulty of meeting the 12-node standard, with the purpose of accurate tumor stage and favorable prognosis. |
| first_indexed | 2024-04-13T14:36:36Z |
| format | Article |
| id | doaj.art-fe52c32d136d450bb344c0f3a7ac5278 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T14:36:36Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-fe52c32d136d450bb344c0f3a7ac52782022-12-22T02:43:01ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-07-011210.3389/fonc.2022.938996938996A Preoperative Scoring System to Predict the Risk of Inadequate Lymph Node Count in Rectal CancerHao ZhangChunlin WangYunxiao LiuHanqing HuGuiyu WangPurposeThe aim of this study was to develop and validate a preoperative scoring system to stratify rectal cancer (RC) patients with different risks of inadequate lymph node examination.MethodsA total of 1,375 stage I–III RC patients between 2011 and 2020 from the Second Affiliated Hospital of Harbin Medical University were included in the retrospective study and randomly divided into a development set (n = 688) and a validation set (n = 687). The logistic regression model was used to determine independent factors contributing to lymph node count (LNC) < 12. A preoperative scoring system was constructed based on beta (β) coefficients. The area under the receiver operating curve (AUC) was used to test model discrimination.ResultsPreoperative significant indicators related to LNC < 12 included age, tumor size, tumor location, and CEA. The AUCs of the scoring system for development and validation sets were 0.694 (95% CI = 0.648–0.741) and 0.666 (95% CI = 0.615–0.716), respectively. Patients who scored 0–2, 3–4, and 5–6 were classified into the low-risk group, medium-risk group, and high-risk group, respectively.ConclusionsThe preoperative scoring system could identify RC patients with high risk of inadequate lymphadenectomy accurately and further provide a reference to perform preoperative lymph node staining in targeted patients to reduce the difficulty of meeting the 12-node standard, with the purpose of accurate tumor stage and favorable prognosis.https://www.frontiersin.org/articles/10.3389/fonc.2022.938996/fullrectal cancerlymph node examinationpreoperative factorscoring systemrisk model |
| spellingShingle | Hao Zhang Chunlin Wang Yunxiao Liu Hanqing Hu Guiyu Wang A Preoperative Scoring System to Predict the Risk of Inadequate Lymph Node Count in Rectal Cancer Frontiers in Oncology rectal cancer lymph node examination preoperative factor scoring system risk model |
| title | A Preoperative Scoring System to Predict the Risk of Inadequate Lymph Node Count in Rectal Cancer |
| title_full | A Preoperative Scoring System to Predict the Risk of Inadequate Lymph Node Count in Rectal Cancer |
| title_fullStr | A Preoperative Scoring System to Predict the Risk of Inadequate Lymph Node Count in Rectal Cancer |
| title_full_unstemmed | A Preoperative Scoring System to Predict the Risk of Inadequate Lymph Node Count in Rectal Cancer |
| title_short | A Preoperative Scoring System to Predict the Risk of Inadequate Lymph Node Count in Rectal Cancer |
| title_sort | preoperative scoring system to predict the risk of inadequate lymph node count in rectal cancer |
| topic | rectal cancer lymph node examination preoperative factor scoring system risk model |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.938996/full |
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