Targeted mutagenesis of the herpesvirus fusogen central helix captures transition states

Targeted mutagenesis of the herpesvirus fusogen central helix captures transition states

Abstract Herpesviruses remain a burden for animal and human health, including the medically important varicella-zoster virus (VZV). Membrane fusion mediated by conserved core glycoproteins, the fusogen gB and the heterodimer gH-gL, enables herpesvirus cell entry. The ectodomain of gB orthologs has f...

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Bibliographic Details
Main Authors: Momei Zhou, Benjamin Vollmer, Emily Machala, Muyuan Chen, Kay Grünewald, Ann M. Arvin, Wah Chiu, Stefan L. Oliver
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43011-w

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