Wnt/β-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL

Wnt/β-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL

HIV infection mediates the apoptosis of lymphocytes, the mechanism of which is multifaceted. Here, we evaluated the role of Wnt/β-catenin signaling in HIV-associated T cell apoptosis, as Wnt/β-catenin regulates the transcriptional activity of genes impacting apoptosis. We specifically investigated t...

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Bibliographic Details
Main Authors: Yasmeen A. Albalawi, Srinivas D. Narasipura, Lena Al-Harthi
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Viruses
Subjects:
HIV
apoptosis
Wnt/β-catenin pathway
CD4 T cells
CD4<sup>dim</sup>CD8<sup>bright</sup> T cells
Bcl-xL
Online Access:https://www.mdpi.com/1999-4915/14/7/1469

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