Fabrication of the Rapid Self-Assembly Hydrogels Loaded with Luteolin: Their Structural Characteristics and Protection Effect on Ulcerative Colitis
Luteolin (LUT) is a fat-soluble flavonoid known for its strong antioxidant and anti-inflammatory properties. Nonetheless, its use in the food industry has been limited due to its low water solubility and bioavailability. In this study, hyaluronic acid, histidine, and luteolin were self-assembled to...
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| Format: | Article |
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MDPI AG
2024-04-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/13/7/1105 |
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| author | Xin Bi Han Peng Hua Xiong Lihua Xiao Hua Zhang Jiang Li Yong Sun |
| author_facet | Xin Bi Han Peng Hua Xiong Lihua Xiao Hua Zhang Jiang Li Yong Sun |
| author_sort | Xin Bi |
| collection | DOAJ |
| description | Luteolin (LUT) is a fat-soluble flavonoid known for its strong antioxidant and anti-inflammatory properties. Nonetheless, its use in the food industry has been limited due to its low water solubility and bioavailability. In this study, hyaluronic acid, histidine, and luteolin were self-assembled to construct tubular network hydrogels (HHL) to improve the gastrointestinal stability, bioavailability, and stimulation response of LUT. As anticipated, the HHL hydrogel’s mechanical strength and adhesion allow it to withstand the challenging gastrointestinal environment and effectively extend the duration of drug presence in the body. In vivo anti-inflammatory experiments showed that HHL hydrogel could successfully alleviate colitis induced by dextran sulfate sodium (DSS) in mice by reducing intestinal inflammation and restoring the integrity of the intestinal barrier. Moreover, HHL hydrogel also regulated the intestinal microorganisms of mice and promoted the production of short-chain fatty acids. The HHL hydrogel group demonstrated a notably superior treatment effect compared to the LUT group alone. The hydrogel delivery system is a novel method to improve the absorption of LUT, increasing its bioavailability and enhancing its pharmaceutical effects. |
| first_indexed | 2024-04-24T10:45:07Z |
| format | Article |
| id | doaj.art-fe54472d0dfd4d12a966e01f1eef63c6 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-04-24T10:45:07Z |
| publishDate | 2024-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-fe54472d0dfd4d12a966e01f1eef63c62024-04-12T13:18:41ZengMDPI AGFoods2304-81582024-04-01137110510.3390/foods13071105Fabrication of the Rapid Self-Assembly Hydrogels Loaded with Luteolin: Their Structural Characteristics and Protection Effect on Ulcerative ColitisXin Bi0Han Peng1Hua Xiong2Lihua Xiao3Hua Zhang4Jiang Li5Yong Sun6State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, ChinaDepartment of Food Science and Technology, University of California, Davis, 1 Shields Ave., Davis, CA 95616, USAState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, ChinaState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, ChinaCollege of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, ChinaCollege of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, ChinaState Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, ChinaLuteolin (LUT) is a fat-soluble flavonoid known for its strong antioxidant and anti-inflammatory properties. Nonetheless, its use in the food industry has been limited due to its low water solubility and bioavailability. In this study, hyaluronic acid, histidine, and luteolin were self-assembled to construct tubular network hydrogels (HHL) to improve the gastrointestinal stability, bioavailability, and stimulation response of LUT. As anticipated, the HHL hydrogel’s mechanical strength and adhesion allow it to withstand the challenging gastrointestinal environment and effectively extend the duration of drug presence in the body. In vivo anti-inflammatory experiments showed that HHL hydrogel could successfully alleviate colitis induced by dextran sulfate sodium (DSS) in mice by reducing intestinal inflammation and restoring the integrity of the intestinal barrier. Moreover, HHL hydrogel also regulated the intestinal microorganisms of mice and promoted the production of short-chain fatty acids. The HHL hydrogel group demonstrated a notably superior treatment effect compared to the LUT group alone. The hydrogel delivery system is a novel method to improve the absorption of LUT, increasing its bioavailability and enhancing its pharmaceutical effects.https://www.mdpi.com/2304-8158/13/7/1105ulcerative colitisluteolinhydrogelsbioavailabilitystimulation response |
| spellingShingle | Xin Bi Han Peng Hua Xiong Lihua Xiao Hua Zhang Jiang Li Yong Sun Fabrication of the Rapid Self-Assembly Hydrogels Loaded with Luteolin: Their Structural Characteristics and Protection Effect on Ulcerative Colitis Foods ulcerative colitis luteolin hydrogels bioavailability stimulation response |
| title | Fabrication of the Rapid Self-Assembly Hydrogels Loaded with Luteolin: Their Structural Characteristics and Protection Effect on Ulcerative Colitis |
| title_full | Fabrication of the Rapid Self-Assembly Hydrogels Loaded with Luteolin: Their Structural Characteristics and Protection Effect on Ulcerative Colitis |
| title_fullStr | Fabrication of the Rapid Self-Assembly Hydrogels Loaded with Luteolin: Their Structural Characteristics and Protection Effect on Ulcerative Colitis |
| title_full_unstemmed | Fabrication of the Rapid Self-Assembly Hydrogels Loaded with Luteolin: Their Structural Characteristics and Protection Effect on Ulcerative Colitis |
| title_short | Fabrication of the Rapid Self-Assembly Hydrogels Loaded with Luteolin: Their Structural Characteristics and Protection Effect on Ulcerative Colitis |
| title_sort | fabrication of the rapid self assembly hydrogels loaded with luteolin their structural characteristics and protection effect on ulcerative colitis |
| topic | ulcerative colitis luteolin hydrogels bioavailability stimulation response |
| url | https://www.mdpi.com/2304-8158/13/7/1105 |
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