Allogeneic leukocytes in cardiac surgery: Good or bad?
Worldwide, cardiac surgery is a common procedure requiring a large quantity of allogeneic blood products, which are associated with postoperative complications. Leukocytes present in blood products may play a role in these complications, which are referred to as transfusion-related immunomodulation...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2011-08-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-76983 |
| _version_ | 1797912474936147968 |
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| author | Yavuz M. Bilgin Anneke Brand |
| author_facet | Yavuz M. Bilgin Anneke Brand |
| author_sort | Yavuz M. Bilgin |
| collection | DOAJ |
| description | Worldwide, cardiac surgery is a common procedure requiring a large quantity of allogeneic blood products, which are associated with postoperative complications. Leukocytes present in blood products may play a role in these complications, which are referred to as transfusion-related immunomodulation (TRIM). Several randomized controlled trials (RCTs) in different settings investigated the effects of allogeneic leukocytes in red blood cells (RBCs). Cardiac surgery studies reported a reduction in postoperative infections and mortality in patients that received leukocyte-reduced RBCs compared with leukocyte-containing RBCs; this was mainly due to more deaths due to infections and multiple organ dysfunction syndrome (MODS) in the group that received leukocyte-containing RBCs. Patients with postoperative complications had higher concentrations of inflammatory mediators. These findings suggest that leukocyte-containing transfusion during cardiac surgery induces a second insult to the systemic inflammatory response. In the present review we discuss the possible role of blood transfusions in cardiac surgery. Especially, we focus on the possible role of allogeneic leukocytes associated with postoperative complications after cardiac surgery. |
| first_indexed | 2024-04-10T11:56:32Z |
| format | Article |
| id | doaj.art-fe5471493ec04027ace4e27183b43a3f |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T11:56:32Z |
| publishDate | 2011-08-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-fe5471493ec04027ace4e27183b43a3f2023-02-15T16:16:47ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632011-08-0128316016910.5152/tjh.2011.49TJH-76983Allogeneic leukocytes in cardiac surgery: Good or bad?Yavuz M. Bilgin0Anneke Brand1Leiden University Medical, Department Of Immunohematology And Blood Transfusion Center, And Sanquin Bloodbank South West Region, Leiden, The NetherlandsLeiden University Medical, Department Of Immunohematology And Blood Transfusion Center, And Sanquin Bloodbank South West Region, Leiden, The NetherlandsWorldwide, cardiac surgery is a common procedure requiring a large quantity of allogeneic blood products, which are associated with postoperative complications. Leukocytes present in blood products may play a role in these complications, which are referred to as transfusion-related immunomodulation (TRIM). Several randomized controlled trials (RCTs) in different settings investigated the effects of allogeneic leukocytes in red blood cells (RBCs). Cardiac surgery studies reported a reduction in postoperative infections and mortality in patients that received leukocyte-reduced RBCs compared with leukocyte-containing RBCs; this was mainly due to more deaths due to infections and multiple organ dysfunction syndrome (MODS) in the group that received leukocyte-containing RBCs. Patients with postoperative complications had higher concentrations of inflammatory mediators. These findings suggest that leukocyte-containing transfusion during cardiac surgery induces a second insult to the systemic inflammatory response. In the present review we discuss the possible role of blood transfusions in cardiac surgery. Especially, we focus on the possible role of allogeneic leukocytes associated with postoperative complications after cardiac surgery.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-76983blood transfusionstransfusion-related immunomodulationleukodepletioninfectionsmortalitycardiac surgery |
| spellingShingle | Yavuz M. Bilgin Anneke Brand Allogeneic leukocytes in cardiac surgery: Good or bad? Turkish Journal of Hematology blood transfusions transfusion-related immunomodulation leukodepletion infections mortality cardiac surgery |
| title | Allogeneic leukocytes in cardiac surgery: Good or bad? |
| title_full | Allogeneic leukocytes in cardiac surgery: Good or bad? |
| title_fullStr | Allogeneic leukocytes in cardiac surgery: Good or bad? |
| title_full_unstemmed | Allogeneic leukocytes in cardiac surgery: Good or bad? |
| title_short | Allogeneic leukocytes in cardiac surgery: Good or bad? |
| title_sort | allogeneic leukocytes in cardiac surgery good or bad |
| topic | blood transfusions transfusion-related immunomodulation leukodepletion infections mortality cardiac surgery |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-76983 |
| work_keys_str_mv | AT yavuzmbilgin allogeneicleukocytesincardiacsurgerygoodorbad AT annekebrand allogeneicleukocytesincardiacsurgerygoodorbad |