Safety of Lavender Oil-Loaded Niosomes for In Vitro Culture and Biomedical Applications
(1) Background: Essential oils have long been used as therapeutic agents. Lavender (<i>Lavandula angustifolia</i>) oil (LO) is an antispasmodic, anticonvulsant, relaxant, painkilling, and antimicrobial essential oil investigated as a natural substance for biomedical therapies. Nanopartic...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/12/12/1999 |
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| author | Janice de M. V. Vilela Saeid Moghassemi Arezoo Dadashzadeh Marie-Madeleine Dolmans Ricardo B. Azevedo Christiani A. Amorim |
| author_facet | Janice de M. V. Vilela Saeid Moghassemi Arezoo Dadashzadeh Marie-Madeleine Dolmans Ricardo B. Azevedo Christiani A. Amorim |
| author_sort | Janice de M. V. Vilela |
| collection | DOAJ |
| description | (1) Background: Essential oils have long been used as therapeutic agents. Lavender (<i>Lavandula angustifolia</i>) oil (LO) is an antispasmodic, anticonvulsant, relaxant, painkilling, and antimicrobial essential oil investigated as a natural substance for biomedical therapies. Nanoparticles have shown significant promise in improving drug delivery and efficacy. Considering these benefits, the aim of this study was to evaluate the toxicity of LO and lavender oil niosomes (LONs) in stem cells and myofibroblast models cultured in vitro. (2) Methods: Adipose tissue-derived stem cells and myometrial cells were cultured with LO or LONs at different concentrations (0, 0.016%, 0.031%, and 0.063%) and toxicity was evaluated with PrestoBlue™ and live/dead assay using calcein and ethidium homodimer. (3) Results: Cell viability was similar to controls in all groups, except in 0.063% LO for myometrial cells, which showed lower viability than the control medium. (4) Conclusion: These results suggest that both LO and LONs are safe for cell culture and may be used for pharmaceutical and biomedical therapies in future applications in regenerative medicine. |
| first_indexed | 2024-03-09T22:53:48Z |
| format | Article |
| id | doaj.art-fe54eab356c8479989114fba1830e3b3 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-09T22:53:48Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-fe54eab356c8479989114fba1830e3b32023-11-23T18:15:51ZengMDPI AGNanomaterials2079-49912022-06-011212199910.3390/nano12121999Safety of Lavender Oil-Loaded Niosomes for In Vitro Culture and Biomedical ApplicationsJanice de M. V. Vilela0Saeid Moghassemi1Arezoo Dadashzadeh2Marie-Madeleine Dolmans3Ricardo B. Azevedo4Christiani A. Amorim5Pôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, 1200 Brussels, BelgiumPôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, 1200 Brussels, BelgiumPôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, 1200 Brussels, BelgiumPôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, 1200 Brussels, BelgiumLaboratory of Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasília, Brasília 70910-900, BrazilPôle de Recherche en Gynécologie, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, 1200 Brussels, Belgium(1) Background: Essential oils have long been used as therapeutic agents. Lavender (<i>Lavandula angustifolia</i>) oil (LO) is an antispasmodic, anticonvulsant, relaxant, painkilling, and antimicrobial essential oil investigated as a natural substance for biomedical therapies. Nanoparticles have shown significant promise in improving drug delivery and efficacy. Considering these benefits, the aim of this study was to evaluate the toxicity of LO and lavender oil niosomes (LONs) in stem cells and myofibroblast models cultured in vitro. (2) Methods: Adipose tissue-derived stem cells and myometrial cells were cultured with LO or LONs at different concentrations (0, 0.016%, 0.031%, and 0.063%) and toxicity was evaluated with PrestoBlue™ and live/dead assay using calcein and ethidium homodimer. (3) Results: Cell viability was similar to controls in all groups, except in 0.063% LO for myometrial cells, which showed lower viability than the control medium. (4) Conclusion: These results suggest that both LO and LONs are safe for cell culture and may be used for pharmaceutical and biomedical therapies in future applications in regenerative medicine.https://www.mdpi.com/2079-4991/12/12/1999drug delivery systemsniosomeessential oilsregenerative medicine |
| spellingShingle | Janice de M. V. Vilela Saeid Moghassemi Arezoo Dadashzadeh Marie-Madeleine Dolmans Ricardo B. Azevedo Christiani A. Amorim Safety of Lavender Oil-Loaded Niosomes for In Vitro Culture and Biomedical Applications Nanomaterials drug delivery systems niosome essential oils regenerative medicine |
| title | Safety of Lavender Oil-Loaded Niosomes for In Vitro Culture and Biomedical Applications |
| title_full | Safety of Lavender Oil-Loaded Niosomes for In Vitro Culture and Biomedical Applications |
| title_fullStr | Safety of Lavender Oil-Loaded Niosomes for In Vitro Culture and Biomedical Applications |
| title_full_unstemmed | Safety of Lavender Oil-Loaded Niosomes for In Vitro Culture and Biomedical Applications |
| title_short | Safety of Lavender Oil-Loaded Niosomes for In Vitro Culture and Biomedical Applications |
| title_sort | safety of lavender oil loaded niosomes for in vitro culture and biomedical applications |
| topic | drug delivery systems niosome essential oils regenerative medicine |
| url | https://www.mdpi.com/2079-4991/12/12/1999 |
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