Molecular basis of carrageenan-induced cytokines production in macrophages

Molecular basis of carrageenan-induced cytokines production in macrophages

Abstract Background Low molecular weight carrageenan (Cg) is a seaweed-derived sulfated polysaccharide widely used as inflammatory stimulus in preclinical studies. However, the molecular mechanisms of Cg-induced inflammation are not fully elucidated. The present study aimed to investigate the molecu...

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Bibliographic Details
Main Authors: Alexandre H. Lopes, Rangel L. Silva, Miriam D. Fonseca, Francisco I. Gomes, Alexandre G. Maganin, Lucas S. Ribeiro, Lucas Maciel Mauriz Marques, Fernando Q. Cunha, Jose C. Alves-Filho, Dario S. Zamboni, Norberto P. Lopes, Bernardo S. Franklin, Aurélie Gombault, Fernando Silva Ramalho, Valerie F. J. Quesniaux, Isabelle Couillin, Bernhard Ryffel, Thiago M. Cunha
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Cell Communication and Signaling
Subjects:
Carrageenan
Macrophages
IL-1β
NLRP3 Inflammasome
Pannexin-1 channel
Online Access:http://link.springer.com/article/10.1186/s12964-020-00621-x

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