Dietary Intakes of Eggs and Cholesterol in Relation to All‐Cause and Heart Disease Mortality: A Prospective Cohort Study
Background The aim of this study was to identify associations between dietary intakes of eggs and cholesterol and all‐cause and heart disease mortality in a US population. Methods and Results Data from the National Health and Nutrition Examination Survey 1999–2014 were used in this study, which incl...
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| Format: | Article |
| Language: | English |
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Wiley
2020-05-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.119.015743 |
| _version_ | 1818016572268085248 |
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| author | Peng‐Fei Xia Xiong‐Fei Pan Chen Chen Yi Wang Yi Ye An Pan |
| author_facet | Peng‐Fei Xia Xiong‐Fei Pan Chen Chen Yi Wang Yi Ye An Pan |
| author_sort | Peng‐Fei Xia |
| collection | DOAJ |
| description | Background The aim of this study was to identify associations between dietary intakes of eggs and cholesterol and all‐cause and heart disease mortality in a US population. Methods and Results Data from the National Health and Nutrition Examination Survey 1999–2014 were used in this study, which included 37 121 participants ≥20 years of age. Dietary information was assessed via 24‐hour dietary recalls at baseline. Mortality status was documented until December 31, 2015. Cox proportional hazards models were used to examine the associations between dietary intakes of eggs and cholesterol and all‐cause and heart disease mortality. During a median follow‐up of 7.8 years, 4991 deaths were documented, including 870 deaths from heart disease. No significant association was observed between additional daily consumption of half an egg and all‐cause mortality (multivariable‐adjusted hazard ratio, 1.04; 95% CI, 0.96–1.13), or heart disease mortality (0.96; 0.80–1.14). Each 50‐mg/day increase of cholesterol intake was inversely associated with all‐cause mortality among participants with daily intake <250 mg (0.87; 0.77–0.98), but positively associated with all‐cause mortality among participants with daily intake ≥250 mg (1.07; 1.01–1.12). No significant association was found between dietary cholesterol intake and heart disease mortality. Conclusions No significant association was found between egg consumption and mortality in US adults. The association between dietary cholesterol intake and all‐cause mortality depended on the baseline intake levels, with an inverse association in those with lower intake levels (<250 mg/day) but a positive association in those with higher intake levels (≥250 mg/day). |
| first_indexed | 2024-04-14T07:15:24Z |
| format | Article |
| id | doaj.art-fe579f1c870848b5b252da10698bbcaf |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-14T07:15:24Z |
| publishDate | 2020-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-fe579f1c870848b5b252da10698bbcaf2022-12-22T02:06:20ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-05-0191010.1161/JAHA.119.015743Dietary Intakes of Eggs and Cholesterol in Relation to All‐Cause and Heart Disease Mortality: A Prospective Cohort StudyPeng‐Fei Xia0Xiong‐Fei Pan1Chen Chen2Yi Wang3Yi Ye4An Pan5Department of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (incubation) School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (incubation) School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (incubation) School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (incubation) School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (incubation) School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaDepartment of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (incubation) School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei ChinaBackground The aim of this study was to identify associations between dietary intakes of eggs and cholesterol and all‐cause and heart disease mortality in a US population. Methods and Results Data from the National Health and Nutrition Examination Survey 1999–2014 were used in this study, which included 37 121 participants ≥20 years of age. Dietary information was assessed via 24‐hour dietary recalls at baseline. Mortality status was documented until December 31, 2015. Cox proportional hazards models were used to examine the associations between dietary intakes of eggs and cholesterol and all‐cause and heart disease mortality. During a median follow‐up of 7.8 years, 4991 deaths were documented, including 870 deaths from heart disease. No significant association was observed between additional daily consumption of half an egg and all‐cause mortality (multivariable‐adjusted hazard ratio, 1.04; 95% CI, 0.96–1.13), or heart disease mortality (0.96; 0.80–1.14). Each 50‐mg/day increase of cholesterol intake was inversely associated with all‐cause mortality among participants with daily intake <250 mg (0.87; 0.77–0.98), but positively associated with all‐cause mortality among participants with daily intake ≥250 mg (1.07; 1.01–1.12). No significant association was found between dietary cholesterol intake and heart disease mortality. Conclusions No significant association was found between egg consumption and mortality in US adults. The association between dietary cholesterol intake and all‐cause mortality depended on the baseline intake levels, with an inverse association in those with lower intake levels (<250 mg/day) but a positive association in those with higher intake levels (≥250 mg/day).https://www.ahajournals.org/doi/10.1161/JAHA.119.015743cardiovascular diseasecohort studydietary cholesteroleggmortality |
| spellingShingle | Peng‐Fei Xia Xiong‐Fei Pan Chen Chen Yi Wang Yi Ye An Pan Dietary Intakes of Eggs and Cholesterol in Relation to All‐Cause and Heart Disease Mortality: A Prospective Cohort Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiovascular disease cohort study dietary cholesterol egg mortality |
| title | Dietary Intakes of Eggs and Cholesterol in Relation to All‐Cause and Heart Disease Mortality: A Prospective Cohort Study |
| title_full | Dietary Intakes of Eggs and Cholesterol in Relation to All‐Cause and Heart Disease Mortality: A Prospective Cohort Study |
| title_fullStr | Dietary Intakes of Eggs and Cholesterol in Relation to All‐Cause and Heart Disease Mortality: A Prospective Cohort Study |
| title_full_unstemmed | Dietary Intakes of Eggs and Cholesterol in Relation to All‐Cause and Heart Disease Mortality: A Prospective Cohort Study |
| title_short | Dietary Intakes of Eggs and Cholesterol in Relation to All‐Cause and Heart Disease Mortality: A Prospective Cohort Study |
| title_sort | dietary intakes of eggs and cholesterol in relation to all cause and heart disease mortality a prospective cohort study |
| topic | cardiovascular disease cohort study dietary cholesterol egg mortality |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.119.015743 |
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