Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory
The noradrenergic system is implicated in neuropathologies contributing to major disorders of the memory, including post-traumatic stress disorder and Alzheimer’s disease. Determining the impact of norepinephrine on cellular function and plasticity is thus essential for making inroads into our under...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/17/9916 |
| _version_ | 1797495115191681024 |
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| author | Sabyasachi Maity Raman Abbaspour David Nahabedian Steven A. Connor |
| author_facet | Sabyasachi Maity Raman Abbaspour David Nahabedian Steven A. Connor |
| author_sort | Sabyasachi Maity |
| collection | DOAJ |
| description | The noradrenergic system is implicated in neuropathologies contributing to major disorders of the memory, including post-traumatic stress disorder and Alzheimer’s disease. Determining the impact of norepinephrine on cellular function and plasticity is thus essential for making inroads into our understanding of these brain conditions, while expanding our capacity for treating them. Norepinephrine is a neuromodulator within the mammalian central nervous system which plays important roles in cognition and associated synaptic plasticity. Specifically, norepinephrine regulates the formation of memory through the stimulation of β-ARs, increasing the dynamic range of synaptic modifiability. The mechanisms through which NE influences neural circuit function have been extended to the level of the epigenome. This review focuses on recent insights into how the noradrenergic recruitment of epigenetic modifications, including DNA methylation and post-translational modification of histones, contribute to homo- and heterosynaptic plasticity. These advances will be placed in the context of synaptic changes associated with memory formation and linked to brain disorders and neurotherapeutic applications. |
| first_indexed | 2024-03-10T01:43:50Z |
| format | Article |
| id | doaj.art-fe58a626b4fd40988fa59f71b5715547 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:43:50Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-fe58a626b4fd40988fa59f71b57155472023-11-23T13:19:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012317991610.3390/ijms23179916Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for MemorySabyasachi Maity0Raman Abbaspour1David Nahabedian2Steven A. Connor3Department of Physiology, Neuroscience, and Behavioral Sciences, St. George’s University School of Medicine, True Blue FZ818, GrenadaDepartment of Biology, York University, 4700 Keele Street, Toronto, ON M3J 1P3, CanadaThe Center for Biomedical Visualization, Department of Anatomical Sciences, St. George’s University School of Medicine, True Blue FZ818, GrenadaDepartment of Biology, York University, 4700 Keele Street, Toronto, ON M3J 1P3, CanadaThe noradrenergic system is implicated in neuropathologies contributing to major disorders of the memory, including post-traumatic stress disorder and Alzheimer’s disease. Determining the impact of norepinephrine on cellular function and plasticity is thus essential for making inroads into our understanding of these brain conditions, while expanding our capacity for treating them. Norepinephrine is a neuromodulator within the mammalian central nervous system which plays important roles in cognition and associated synaptic plasticity. Specifically, norepinephrine regulates the formation of memory through the stimulation of β-ARs, increasing the dynamic range of synaptic modifiability. The mechanisms through which NE influences neural circuit function have been extended to the level of the epigenome. This review focuses on recent insights into how the noradrenergic recruitment of epigenetic modifications, including DNA methylation and post-translational modification of histones, contribute to homo- and heterosynaptic plasticity. These advances will be placed in the context of synaptic changes associated with memory formation and linked to brain disorders and neurotherapeutic applications.https://www.mdpi.com/1422-0067/23/17/9916norepinephrinememoryhippocampusbeta-adrenergic receptorssynaptic plasticityepigenome |
| spellingShingle | Sabyasachi Maity Raman Abbaspour David Nahabedian Steven A. Connor Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory International Journal of Molecular Sciences norepinephrine memory hippocampus beta-adrenergic receptors synaptic plasticity epigenome |
| title | Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory |
| title_full | Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory |
| title_fullStr | Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory |
| title_full_unstemmed | Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory |
| title_short | Norepinephrine, beyond the Synapse: Coordinating Epigenetic Codes for Memory |
| title_sort | norepinephrine beyond the synapse coordinating epigenetic codes for memory |
| topic | norepinephrine memory hippocampus beta-adrenergic receptors synaptic plasticity epigenome |
| url | https://www.mdpi.com/1422-0067/23/17/9916 |
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