Beta-band functional connectivity is reorganized in mild cognitive impairment after combined computerized physical and cognitive training
Physical and cognitive idleness constitute significant risk factors for the clinical manifestation of age-related neurodegenerative diseases. In contrast, a physically and cognitively active lifestyle may restructure age-declined neuronal networks enhancing neuroplasticity. The present study, invest...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00055/full |
| _version_ | 1828435942088638464 |
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| author | Manousos eKlados Manousos eKlados Charis eStyliadis Christos A Frantzidis Evangelos eParaskevopoulos Panagiotis D Bamidis |
| author_facet | Manousos eKlados Manousos eKlados Charis eStyliadis Christos A Frantzidis Evangelos eParaskevopoulos Panagiotis D Bamidis |
| author_sort | Manousos eKlados |
| collection | DOAJ |
| description | Physical and cognitive idleness constitute significant risk factors for the clinical manifestation of age-related neurodegenerative diseases. In contrast, a physically and cognitively active lifestyle may restructure age-declined neuronal networks enhancing neuroplasticity. The present study, investigated the changes of brain’s functional network in a group of elderly individuals at risk for dementia that were induced by a combined cognitive and physical intervention scheme. Fifty seniors meeting Petersen’s criteria of Mild Cognitive Impairment were equally divided into an experimental (LLM), and an active control (AC) group. Resting state electroencephalogram (EEG) was measured before and after the intervention. Functional networks were estimated by computing the magnitude square coherence between the time series of all available cortical sources as computed by standardized low resolution brain electromagnetic tomography (sLORETA). A statistical model was used to form groups’ characteristic weighted graphs. The introduced modulation was assessed by networks' density and nodes’ strength. Results focused on the beta band (12-30 Hz) in which the difference of the two networks' density is maximum, indicating that the structure of the LLM cortical network changes significantly due to the intervention, in contrast to the network of AC. The node strength of LLM participants in the beta band presents a higher number of bilateral connections in the occipital, parietal, temporal and prefrontal regions after the intervention. Our results show that the combined training scheme reorganizes the beta-band functional connectivity of MCI patients. |
| first_indexed | 2024-12-10T19:16:17Z |
| format | Article |
| id | doaj.art-fe58b06580c641f8944fb91c4396b870 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-10T19:16:17Z |
| publishDate | 2016-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-fe58b06580c641f8944fb91c4396b8702022-12-22T01:36:35ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2016-02-011010.3389/fnins.2016.00055152218Beta-band functional connectivity is reorganized in mild cognitive impairment after combined computerized physical and cognitive trainingManousos eKlados0Manousos eKlados1Charis eStyliadis2Christos A Frantzidis3Evangelos eParaskevopoulos4Panagiotis D Bamidis5Max Planck Institute for Human Cognitive & Brain SciencesAristotle University of Thessaloniki, GreeceAristotle University of Thessaloniki, GreeceAristotle University of Thessaloniki, GreeceAristotle University of Thessaloniki, GreeceAristotle University of Thessaloniki, GreecePhysical and cognitive idleness constitute significant risk factors for the clinical manifestation of age-related neurodegenerative diseases. In contrast, a physically and cognitively active lifestyle may restructure age-declined neuronal networks enhancing neuroplasticity. The present study, investigated the changes of brain’s functional network in a group of elderly individuals at risk for dementia that were induced by a combined cognitive and physical intervention scheme. Fifty seniors meeting Petersen’s criteria of Mild Cognitive Impairment were equally divided into an experimental (LLM), and an active control (AC) group. Resting state electroencephalogram (EEG) was measured before and after the intervention. Functional networks were estimated by computing the magnitude square coherence between the time series of all available cortical sources as computed by standardized low resolution brain electromagnetic tomography (sLORETA). A statistical model was used to form groups’ characteristic weighted graphs. The introduced modulation was assessed by networks' density and nodes’ strength. Results focused on the beta band (12-30 Hz) in which the difference of the two networks' density is maximum, indicating that the structure of the LLM cortical network changes significantly due to the intervention, in contrast to the network of AC. The node strength of LLM participants in the beta band presents a higher number of bilateral connections in the occipital, parietal, temporal and prefrontal regions after the intervention. Our results show that the combined training scheme reorganizes the beta-band functional connectivity of MCI patients.http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00055/fullAgingElectroencephalographyMild Cognitive Impairmentneuroplasticitycognitive trainingbrain plasticity |
| spellingShingle | Manousos eKlados Manousos eKlados Charis eStyliadis Christos A Frantzidis Evangelos eParaskevopoulos Panagiotis D Bamidis Beta-band functional connectivity is reorganized in mild cognitive impairment after combined computerized physical and cognitive training Frontiers in Neuroscience Aging Electroencephalography Mild Cognitive Impairment neuroplasticity cognitive training brain plasticity |
| title | Beta-band functional connectivity is reorganized in mild cognitive impairment after combined computerized physical and cognitive training |
| title_full | Beta-band functional connectivity is reorganized in mild cognitive impairment after combined computerized physical and cognitive training |
| title_fullStr | Beta-band functional connectivity is reorganized in mild cognitive impairment after combined computerized physical and cognitive training |
| title_full_unstemmed | Beta-band functional connectivity is reorganized in mild cognitive impairment after combined computerized physical and cognitive training |
| title_short | Beta-band functional connectivity is reorganized in mild cognitive impairment after combined computerized physical and cognitive training |
| title_sort | beta band functional connectivity is reorganized in mild cognitive impairment after combined computerized physical and cognitive training |
| topic | Aging Electroencephalography Mild Cognitive Impairment neuroplasticity cognitive training brain plasticity |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00055/full |
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